======= RFC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFC2
  * **<color #00a2e8>Official Name</color>**: replication factor C subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5982|5982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35250|P35250]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rep fac C|
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication factor C complex|
|regulation of DNA-directed DNA polymerase activity|
|positive regulation of DNA-directed DNA polymerase activity|
|Ctf18 RFC-like complex|
|DNA clamp loader activity|
|single-stranded DNA helicase activity|
|error-free translesion synthesis|
|error-prone translesion synthesis|
|nucleotide-excision repair, DNA gap filling|
|telomere maintenance via semi-conservative replication|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|regulation of DNA-dependent DNA replication|
|positive regulation of DNA biosynthetic process|
|transcription-coupled nucleotide-excision repair|
|telomere maintenance|
|telomere organization|
|regulation of DNA replication|
|DNA biosynthetic process|
|DNA duplex unwinding|
|nucleotide-excision repair|
|regulation of DNA biosynthetic process|
|DNA geometric change|
|DNA-dependent DNA replication|
|regulation of signal transduction by p53 class mediator|
|positive regulation of DNA metabolic process|
|DNA replication|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|enzyme binding|
|regulation of DNA metabolic process|
|DNA repair|
|positive regulation of transferase activity|
|detection of stimulus|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular homeostasis|
|regulation of transferase activity|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.36|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.26|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.96|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.88|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.84|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.8|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.06|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.12|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.22|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 290
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFC2 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>