======= RFC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFC5
  * **<color #00a2e8>Official Name</color>**: replication factor C subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5985|5985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40937|P40937]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600407|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. {ECO:0000269|PubMed:8999859}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad17|
|AAA|
|Rep fac C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication factor C complex|
|positive regulation of DNA-directed DNA polymerase activity|
|regulation of DNA-directed DNA polymerase activity|
|Ctf18 RFC-like complex|
|DNA clamp loader activity|
|single-stranded DNA helicase activity|
|error-prone translesion synthesis|
|error-free translesion synthesis|
|nucleotide-excision repair, DNA gap filling|
|telomere maintenance via semi-conservative replication|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|regulation of DNA-dependent DNA replication|
|positive regulation of DNA biosynthetic process|
|transcription-coupled nucleotide-excision repair|
|telomere maintenance|
|telomere organization|
|regulation of DNA replication|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA duplex unwinding|
|regulation of DNA biosynthetic process|
|DNA geometric change|
|DNA-dependent DNA replication|
|regulation of signal transduction by p53 class mediator|
|positive regulation of DNA metabolic process|
|DNA replication|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|enzyme binding|
|regulation of DNA metabolic process|
|DNA repair|
|positive regulation of transferase activity|
|detection of stimulus|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular homeostasis|
|regulation of transferase activity|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.14|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.1|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.05|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.86|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.79|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.78|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.7|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 539/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|26/28|
|bone|23/26|
|breast|25/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|17/21|
|liver|16/20|
|lung|55/75|
|lymphocyte|13/16|
|ovary|21/26|
|pancreas|14/24|
|peripheral nervous system|14/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 162
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFC5 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>