======= RHOB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOB
  * **<color #00a2e8>Official Name</color>**: ras homolog family member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388|388]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62745|P62745]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269|PubMed:10508588, ECO:0000269|PubMed:15226397, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:9478917}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division site|
|morphogenesis of an endothelium|
|endothelial tube morphogenesis|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|endosome to lysosome transport|
|cleavage furrow|
|actin filament bundle assembly|
|actin filament bundle organization|
|mitotic cytokinesis|
|cellular response to ionizing radiation|
|cellular response to hydrogen peroxide|
|GDP binding|
|Rho protein signal transduction|
|endothelium development|
|cytoskeleton-dependent cytokinesis|
|positive regulation of endothelial cell migration|
|cytokinesis|
|lysosomal transport|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|late endosome membrane|
|cellular response to reactive oxygen species|
|cell cortex|
|positive regulation of epithelial cell migration|
|vacuolar transport|
|response to ionizing radiation|
|regulation of cell shape|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|cellular response to radiation|
|positive regulation of vasculature development|
|response to reactive oxygen species|
|establishment or maintenance of cell polarity|
|endosome membrane|
|cellular response to toxic substance|
|regulation of epithelial cell migration|
|cellular response to oxidative stress|
|actin filament organization|
|Ras protein signal transduction|
|early endosome|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|response to antibiotic|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|angiogenesis|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|negative regulation of locomotion|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|response to oxidative stress|
|regulation of actin filament-based process|
|GTP binding|
|cellular response to drug|
|blood vessel morphogenesis|
|focal adhesion|
|morphogenesis of an epithelium|
|response to radiation|
|supramolecular fiber organization|
|protein kinase binding|
|blood vessel development|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|tissue morphogenesis|
|actin filament-based process|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|intracellular protein transport|
|regulation of cellular component movement|
|cell cycle process|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|cytoskeleton organization|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.7|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.71|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.76|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.85|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOB Expression in NALM6 Cells: 2.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>