======= RHOF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOF
  * **<color #00a2e8>Official Name</color>**: ras homolog family member F, filopodia associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54509|54509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBH0|Q9HBH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division site|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|actin filament bundle assembly|
|actin filament bundle organization|
|Rho protein signal transduction|
|secretory granule membrane|
|cell cortex|
|regulation of cell shape|
|establishment or maintenance of cell polarity|
|actin filament organization|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|regulation of actin filament-based process|
|GTP binding|
|supramolecular fiber organization|
|protein kinase binding|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cytoskeleton organization|
|actin filament-based process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|cytoskeleton organization|
|secretion|
|regulation of organelle organization|
|locomotion|
|movement of cell or subcellular component|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.71|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.71|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.83|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7205
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOF Expression in NALM6 Cells: 3.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>