======= RILPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RILPL1
  * **<color #00a2e8>Official Name</color>**: Rab interacting lysosomal protein like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=353116|353116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5EBL4|Q5EBL4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RILPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RILPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RILP|
|Jnk-SapK ap N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transport from ciliary membrane to plasma membrane|
|protein transport within lipid bilayer|
|small GTPase binding|
|dynein light intermediate chain binding|
|epithelial cell morphogenesis|
|establishment of protein localization to plasma membrane|
|localization within membrane|
|ciliary basal body|
|protein dimerization activity|
|protein localization to plasma membrane|
|epithelial cell development|
|cilium|
|protein localization to cell periphery|
|establishment of protein localization to membrane|
|regulation of neuron death|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|centrosome|
|cell morphogenesis involved in differentiation|
|epithelial cell differentiation|
|cell morphogenesis|
|organelle assembly|
|cellular component morphogenesis|
|membrane organization|
|intracellular protein transport|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|regulation of cell death|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.76|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.75|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.83|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.622|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.456|
|[[:human genes:t:twistnb|TWISTNB]]|0.456|
|[[:human genes:p:prim1|PRIM1]]|0.456|
|[[:human genes:p:psmd1|PSMD1]]|0.448|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.437|
|[[:human genes:t:tceb3c|TCEB3C]]|0.436|
|[[:human genes:c:c14orf93|C14orf93]]|0.433|
|[[:human genes:n:npipb8|NPIPB8]]|0.431|
|[[:human genes:r:rps9|RPS9]]|0.425|
|[[:human genes:x:xylt2|XYLT2]]|0.42|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.416|
|[[:human genes:v:vasn|VASN]]|0.415|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.413|
|[[:human genes:c:cdc73|CDC73]]|0.411|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.409|
|[[:human genes:b:bysl|BYSL]]|0.407|
|[[:human genes:c:cdc6|CDC6]]|0.404|
|[[:human genes:p:psmb4|PSMB4]]|0.403|
|[[:human genes:s:sec13|SEC13]]|0.403|
|[[:human genes:s:sf3a1|SF3A1]]|0.402|
|[[:human genes:h:hinfp|HINFP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RILPL1 Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>