======= RIMS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIMS1
  * **<color #00a2e8>Official Name</color>**: regulating synaptic membrane exocytosis 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22999|22999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UR5|Q86UR5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIMS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIMS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606629|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acrosomal vesicle exocytosis|
|cytoskeleton of presynaptic active zone|
|positive regulation of inhibitory postsynaptic potential|
|modulation of inhibitory postsynaptic potential|
|presynaptic active zone cytoplasmic component|
|GTPase regulator activity|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of dendrite extension|
|acrosome reaction|
|regulation of dendrite extension|
|positive regulation of excitatory postsynaptic potential|
|glutamate secretion|
|presynaptic active zone|
|modulation of excitatory postsynaptic potential|
|calcium-ion regulated exocytosis|
|acidic amino acid transport|
|positive regulation of nervous system process|
|synaptic vesicle exocytosis|
|presynaptic membrane|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle cycle|
|ion channel binding|
|vesicle-mediated transport in synapse|
|membrane fusion|
|regulation of nervous system process|
|single fertilization|
|regulation of neurotransmitter transport|
|Rab GTPase binding|
|positive regulation of synaptic transmission|
|positive regulation of cell growth|
|regulation of regulated secretory pathway|
|signal release|
|fertilization|
|positive regulation of developmental growth|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|visual perception|
|regulation of exocytosis|
|sensory perception of light stimulus|
|positive regulation of growth|
|synapse|
|positive regulation of neuron projection development|
|organic acid transport|
|carboxylic acid transport|
|regulation of developmental growth|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cell growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|anion transport|
|regulation of system process|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|sexual reproduction|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|sensory perception|
|intracellular protein transport|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|RNA binding|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIMS1 Expression in NALM6 Cells: 1.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>