======= RIMS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIMS4
  * **<color #00a2e8>Official Name</color>**: regulating synaptic membrane exocytosis 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140730|140730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H426|Q9H426]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIMS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIMS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611601|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates synaptic membrane exocytosis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoskeleton of presynaptic active zone|
|presynaptic active zone cytoplasmic component|
|calcium ion-regulated exocytosis of neurotransmitter|
|synaptic membrane|
|presynaptic active zone|
|calcium-ion regulated exocytosis|
|synaptic vesicle exocytosis|
|presynaptic membrane|
|regulation of synaptic vesicle exocytosis|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|ion channel binding|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|Rab GTPase binding|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|signal release|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|regulation of exocytosis|
|synapse|
|regulation of neurotransmitter levels|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|cell junction|
|regulation of vesicle-mediated transport|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.88|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.81|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.72|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIMS4 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>