======= RIOK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIOK3
  * **<color #00a2e8>Official Name</color>**: RIO kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8780|8780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14730|O14730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIOK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIOK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in regulation of type I interferon (IFN)- dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). {ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:22418843, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:25865883}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to dsDNA|
|cellular response to dsDNA|
|negative regulation of MDA-5 signaling pathway|
|regulation of MDA-5 signaling pathway|
|negative regulation of protein homooligomerization|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|caspase binding|
|preribosome, small subunit precursor|
|negative regulation of protein oligomerization|
|regulation of protein homooligomerization|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|cellular response to dsRNA|
|negative regulation of defense response to virus|
|positive regulation of interferon-beta production|
|cellular response to virus|
|regulation of protein oligomerization|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|maturation of SSU-rRNA|
|regulation of interferon-beta production|
|response to dsRNA|
|ribosomal small subunit biogenesis|
|regulation of defense response to virus|
|positive regulation of type I interferon production|
|negative regulation of response to biotic stimulus|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|negative regulation of protein complex assembly|
|defense response to virus|
|negative regulation of defense response|
|rRNA processing|
|negative regulation of multi-organism process|
|rRNA metabolic process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|chromosome segregation|
|response to virus|
|ribosome biogenesis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|negative regulation of response to external stimulus|
|ncRNA processing|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|positive regulation of defense response|
|ncRNA metabolic process|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|positive regulation of response to external stimulus|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|RNA processing|
|response to organic cyclic compound|
|defense response to other organism|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|negative regulation of response to stimulus|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6440
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIOK3 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>