======= RIPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIPK1
  * **<color #00a2e8>Official Name</color>**: receptor interacting serine/threonine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8737|8737]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13546|Q13546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. {ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|RHIM|
|Pkinase Tyr|
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ATP:ADP antiporter activity|
|ripoptosome assembly involved in necroptotic process|
|ripoptosome assembly|
|positive regulation of necroptotic process|
|positive regulation of programmed necrotic cell death|
|death domain binding|
|positive regulation of hydrogen peroxide-induced cell death|
|ripoptosome|
|necroptotic signaling pathway|
|death-inducing signaling complex|
|positive regulation of response to reactive oxygen species|
|peptidyl-serine autophosphorylation|
|death-inducing signaling complex assembly|
|positive regulation of necrotic cell death|
|JUN kinase kinase kinase activity|
|amyloid fibril formation|
|positive regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of production of miRNAs involved in gene silencing by miRNA|
|positive regulation of cellular response to drug|
|toll-like receptor 3 signaling pathway|
|activation of JNKK activity|
|negative regulation of cardiac muscle cell proliferation|
|T cell apoptotic process|
|positive regulation of macrophage differentiation|
|positive regulation of oxidative stress-induced cell death|
|death receptor binding|
|regulation of nucleobase-containing compound transport|
|regulation of necroptotic process|
|positive regulation of cellular response to oxidative stress|
|lymphocyte apoptotic process|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|positive regulation of response to oxidative stress|
|regulation of production of small RNA involved in gene silencing by RNA|
|regulation of programmed necrotic cell death|
|regulation of macrophage differentiation|
|regulation of hydrogen peroxide-induced cell death|
|necroptotic process|
|positive regulation of gene silencing by miRNA|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|leukocyte apoptotic process|
|positive regulation of posttranscriptional gene silencing|
|regulation of anion transmembrane transport|
|programmed necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|regulation of necrotic cell death|
|necrotic cell death|
|positive regulation of response to drug|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of response to reactive oxygen species|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of cellular response to drug|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|activation of JUN kinase activity|
|regulation of cardiac muscle cell proliferation|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of striated muscle tissue development|
|positive regulation of interleukin-8 production|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of muscle organ development|
|positive regulation of cytokine-mediated signaling pathway|
|negative regulation of muscle tissue development|
|activation of MAPKK activity|
|positive regulation of myeloid leukocyte differentiation|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of response to cytokine stimulus|
|regulation of cardiac muscle tissue growth|
|regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of oxidative stress-induced cell death|
|regulation of heart growth|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|cellular response to hydrogen peroxide|
|positive regulation of JUN kinase activity|
|regulation of cellular response to oxidative stress|
|regulation of cardiac muscle tissue development|
|JNK cascade|
|regulation of response to oxidative stress|
|positive regulation of tumor necrosis factor production|
|regulation of gene silencing by miRNA|
|regulation of JUN kinase activity|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|positive regulation of myeloid cell differentiation|
|regulation of organ growth|
|positive regulation of reactive oxygen species metabolic process|
|regulation of anion transport|
|extrinsic apoptotic signaling pathway|
|toll-like receptor signaling pathway|
|regulation of response to drug|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of developmental growth|
|stress-activated MAPK cascade|
|negative regulation of cell cycle G1/S phase transition|
|protein heterooligomerization|
|regulation of myeloid leukocyte differentiation|
|cellular response to antibiotic|
|tumor necrosis factor-mediated signaling pathway|
|response to hydrogen peroxide|
|pattern recognition receptor signaling pathway|
|regulation of gene silencing|
|cellular response to reactive oxygen species|
|regulation of striated muscle tissue development|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|regulation of cytokine-mediated signaling pathway|
|regulation of cell cycle G1/S phase transition|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of endopeptidase activity|
|peptidyl-serine phosphorylation|
|positive regulation of apoptotic signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of reactive oxygen species metabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|positive regulation of peptidase activity|
|protein autophosphorylation|
|response to reactive oxygen species|
|peptidyl-serine modification|
|receptor complex|
|negative regulation of mitotic cell cycle phase transition|
|endosome membrane|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|membrane raft|
|negative regulation of apoptotic signaling pathway|
|regulation of myeloid cell differentiation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|activation of innate immune response|
|regulation of ion transmembrane transporter activity|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|regulation of leukocyte differentiation|
|regulation of transporter activity|
|protein deubiquitination|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|response to antibiotic|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|protein homooligomerization|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|MAPK cascade|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|supramolecular fiber organization|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|cellular response to growth factor stimulus|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|response to growth factor|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|protein catabolic process|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|viral process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.43|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.15|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.05|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.75|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIPK1 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>