======= RIPK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIPK3
  * **<color #00a2e8>Official Name</color>**: receptor interacting serine/threonine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11035|11035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y572|Q9Y572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIPK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIPK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605817|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|RHIM|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of necroptotic process|
|regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|
|positive regulation of programmed necrotic cell death|
|regulation of CD8-positive, alpha-beta T cell extravasation|
|regulation of activation-induced cell death of T cells|
|regulation of T cell extravasation|
|NF-kappaB-inducing kinase activity|
|positive regulation of ligase activity|
|positive regulation of necrotic cell death|
|amyloid fibril formation|
|regulation of ligase activity|
|lymph node development|
|regulation of necroptotic process|
|regulation of programmed necrotic cell death|
|necroptotic process|
|programmed necrotic cell death|
|regulation of necrotic cell death|
|regulation of cellular extravasation|
|necrotic cell death|
|regulation of T cell mediated cytotoxicity|
|spleen development|
|T cell homeostasis|
|regulation of T cell apoptotic process|
|positive regulation of phosphatase activity|
|regulation of activated T cell proliferation|
|regulation of T cell migration|
|thymus development|
|T cell differentiation in thymus|
|regulation of lymphocyte apoptotic process|
|positive regulation of oxidoreductase activity|
|lymphocyte homeostasis|
|positive regulation of intrinsic apoptotic signaling pathway|
|positive regulation of dephosphorylation|
|regulation of lymphocyte migration|
|I-kappaB kinase/NF-kappaB signaling|
|leukocyte homeostasis|
|cellular response to hydrogen peroxide|
|regulation of T cell mediated immunity|
|regulation of leukocyte mediated cytotoxicity|
|NIK/NF-kappaB signaling|
|regulation of leukocyte apoptotic process|
|regulation of oxidoreductase activity|
|positive regulation of reactive oxygen species metabolic process|
|regulation of interferon-gamma production|
|regulation of cell killing|
|protein heterooligomerization|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|cellular response to reactive oxygen species|
|T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of adaptive immune response|
|positive regulation of apoptotic signaling pathway|
|regulation of phosphatase activity|
|regulation of reactive oxygen species metabolic process|
|protein autophosphorylation|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of dephosphorylation|
|cellular response to toxic substance|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|protein kinase activity|
|cellular response to oxidative stress|
|positive regulation of DNA-binding transcription factor activity|
|protein-containing complex binding|
|transcription coactivator activity|
|apoptotic signaling pathway|
|response to antibiotic|
|regulation of T cell activation|
|activation of protein kinase activity|
|leukocyte differentiation|
|protein homooligomerization|
|protein serine/threonine kinase activity|
|lymphocyte activation|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|gland development|
|regulation of DNA-binding transcription factor activity|
|supramolecular fiber organization|
|regulation of immune effector process|
|response to toxic substance|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|hemopoiesis|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|regulation of cytokine production|
|positive regulation of cell death|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|apoptotic process|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell death|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIPK3 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>