======= RMI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RMI1
  * **<color #00a2e8>Official Name</color>**: RecQ mediated genome instability 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80010|80010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9A7|Q9H9A7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RMI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RMI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1767|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RecQ helicase-Topo III complex|
|reduction of food intake in response to dietary excess|
|resolution of meiotic recombination intermediates|
|meiotic chromosome separation|
|response to dietary excess|
|eating behavior|
|chromosome separation|
|reciprocal meiotic recombination|
|homologous recombination|
|nucleotide binding|
|multicellular organism growth|
|feeding behavior|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|meiosis I|
|meiosis I cell cycle process|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|meiotic nuclear division|
|meiotic cell cycle process|
|response to carbohydrate|
|double-strand break repair|
|regulation of signal transduction by p53 class mediator|
|glucose homeostasis|
|carbohydrate homeostasis|
|DNA replication|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|developmental growth|
|growth|
|response to nutrient levels|
|DNA repair|
|response to extracellular stimulus|
|behavior|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|chemical homeostasis|
|cell cycle|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.36|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.99|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.89|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.82|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.7|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.82|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.02|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.03|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.09|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.19|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|4.44|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|6.88|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|7.95|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|8.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmi2|RMI2]]|0.792|
|[[:human genes:b:blm|BLM]]|0.775|
|[[:human genes:p:pml|PML]]|0.636|
|[[:human genes:t:top3a|TOP3A]]|0.609|
|[[:human genes:s:slfn11|SLFN11]]|0.524|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 149/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|6/28|
|bone|7/26|
|breast|12/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|3/20|
|lung|11/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|4/24|
|peripheral nervous system|3/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|6/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RMI1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>