======= RMI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RMI2
  * **<color #00a2e8>Official Name</color>**: RecQ mediated genome instability 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116028|116028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96E14|Q96E14]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RMI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RMI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of rDNA|
|maintenance of DNA repeat elements|
|negative regulation of double-strand break repair via homologous recombination|
|negative regulation of double-strand break repair|
|negative regulation of DNA repair|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|regulation of DNA recombination|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|regulation of signal transduction by p53 class mediator|
|DNA replication|
|regulation of response to DNA damage stimulus|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|nuclear speck|
|DNA repair|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|regulation of response to stress|
|negative regulation of response to stimulus|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.62|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.59|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.12|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.96|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.7|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.77|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.01|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.3|
|[[:results:exp453|B02 10μM R08 exp453]]|2.33|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.44|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.74|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.27|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|4.76|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|8.12|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|8.5|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmi1|RMI1]]|0.792|
|[[:human genes:b:blm|BLM]]|0.727|
|[[:human genes:t:top3a|TOP3A]]|0.653|
|[[:human genes:p:pml|PML]]|0.631|
|[[:human genes:s:slfn11|SLFN11]]|0.506|
|[[:human genes:r:rrm1|RRM1]]|0.469|
|[[:human genes:p:prkrir|PRKRIR]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RMI2 Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>