======= RND2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RND2
  * **<color #00a2e8>Official Name</color>**: Rho family GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8153|8153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52198|P52198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RND2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RND2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601555|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division site|
|positive regulation of collateral sprouting|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|acrosomal membrane|
|regulation of collateral sprouting|
|actin filament bundle assembly|
|actin filament bundle organization|
|Rho protein signal transduction|
|positive regulation of axonogenesis|
|protein N-terminus binding|
|regulation of extent of cell growth|
|cell cortex|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|establishment or maintenance of cell polarity|
|actin filament organization|
|Ras protein signal transduction|
|early endosome|
|positive regulation of growth|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|regulation of developmental growth|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|GTP binding|
|regulation of cell growth|
|supramolecular fiber organization|
|protein kinase binding|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|actin filament-based process|
|regulation of neuron differentiation|
|regulation of growth|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.74|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RND2 Expression in NALM6 Cells: 2.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>