======= RNF103-CHMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF103-CHMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF103-CHMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.42|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.38|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.25|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.19|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.14|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.13|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.98|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.9|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.84|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.76|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.76|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.72|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.72|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.81|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.94|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF103-CHMP3 Expression in NALM6 Cells: 1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>