======= RNF121 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF121
  * **<color #00a2e8>Official Name</color>**: ring finger protein 121
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55298|55298]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H920|Q9H920]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF121&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF121|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620529|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-rbx1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent ERAD pathway|
|ERAD pathway|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|ubiquitin protein ligase activity|
|response to endoplasmic reticulum stress|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|Golgi membrane|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.95|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.75|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.75|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc38a7|SLC38A7]]|0.508|
|[[:human genes:c:cbwd5|CBWD5]]|0.486|
|[[:human genes:c:cbwd3|CBWD3]]|0.482|
|[[:human genes:c:cbwd6|CBWD6]]|0.482|
|[[:human genes:z:zfand5|ZFAND5]]|0.465|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.455|
|[[:human genes:p:polr2d|POLR2D]]|0.452|
|[[:human genes:s:supt6h|SUPT6H]]|0.444|
|[[:human genes:n:nop16|NOP16]]|0.439|
|[[:human genes:d:ddx56|DDX56]]|0.438|
|[[:human genes:m:mt1e|MT1E]]|0.437|
|[[:human genes:o:ogfr|OGFR]]|0.435|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.435|
|[[:human genes:p:pola1|POLA1]]|0.433|
|[[:human genes:p:psmd3|PSMD3]]|0.433|
|[[:human genes:t:twistnb|TWISTNB]]|0.433|
|[[:human genes:m:med17|MED17]]|0.429|
|[[:human genes:c:copg1|COPG1]]|0.422|
|[[:human genes:h:hap1|HAP1]]|0.421|
|[[:human genes:p:polr2j3|POLR2J3]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.418|
|[[:human genes:c:chd4|CHD4]]|0.417|
|[[:human genes:s:smg1|SMG1]]|0.413|
|[[:human genes:p:psmc2|PSMC2]]|0.412|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.409|
|[[:human genes:p:psmd11|PSMD11]]|0.406|
|[[:human genes:n:nbpf10|NBPF10]]|0.406|
|[[:human genes:p:psma6|PSMA6]]|0.405|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:f:fam86b2|FAM86B2]]|0.405|
|[[:human genes:p:pola2|POLA2]]|0.403|
|[[:human genes:p:psmb4|PSMB4]]|0.403|
|[[:human genes:m:myb|MYB]]|0.4|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2111
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF121 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>