======= RNF216 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF216
  * **<color #00a2e8>Official Name</color>**: ring finger protein 216
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54476|54476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWF9|Q9NWF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF216&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF216|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein catabolic process at synapse|
|protein catabolic process, modulating synaptic transmission|
|postsynaptic endocytic zone|
|regulation of defense response to virus by host|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|protein K48-linked ubiquitination|
|regulation of defense response to virus|
|Schaffer collateral - CA1 synapse|
|regulation of type I interferon production|
|ubiquitin protein ligase activity|
|negative regulation of cytokine production|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|glutamatergic synapse|
|proteasomal protein catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of immune effector process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of cytokine production|
|viral process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|regulation of immune system process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.32|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.96|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.93|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.75|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.73|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.87|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.02|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.1|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.66|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.03|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.3|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.39|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10613
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF216 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>