======= RNMT =======
== Gene Information ==
* **Official Symbol**: RNMT
* **Official Name**: RNA guanine-7 methyltransferase
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8731|8731]]
* **UniProt**: [[https://www.uniprot.org/uniprot/O43148|O43148]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=RNMT&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNMT|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/603514|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.
|Pox MCEL|
|Methyltransf 18|
|Methyltransf 11|
|mRNA cap methyltransferase complex|
|mRNA (guanine-N7-)-methyltransferase activity|
|RNA 5-cap (guanine-N7)-methylation|
|RNA (guanine-N7)-methylation|
|mRNA cap binding complex|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|RNA methylation|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|fibrillar center|
|RNA modification|
|receptor complex|
|macromolecule methylation|
|methylation|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|cellular response to cytokine stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.45|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.21|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.99|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.97|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.95|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.92|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.9|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.84|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311]]|-1.78|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.78|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.77|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.76|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.76|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.76|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.72|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.71|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.73|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.83|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.83|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.85|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.87|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.88|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.94|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.94|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.04|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.06|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.08|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.19|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.24|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.26|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.4|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.51|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.56|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.61|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.64|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.72|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|3.01|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.29|
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.717|
|[[:human genes:r:rptor|RPTOR]]|0.711|
|[[:human genes:g:gmppb|GMPPB]]|0.703|
|[[:human genes:p:pmm2|PMM2]]|0.674|
|[[:human genes:m:med16|MED16]]|0.671|
|[[:human genes:a:alg1|ALG1]]|0.67|
|[[:human genes:d:dpagt1|DPAGT1]]|0.666|
|[[:human genes:h:hspd1|HSPD1]]|0.664|
|[[:human genes:d:dohh|DOHH]]|0.65|
|[[:human genes:g:gfpt1|GFPT1]]|0.646|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.642|
|[[:human genes:g:gnb1l|GNB1L]]|0.64|
|[[:human genes:r:rtcb|RTCB]]|0.628|
|[[:human genes:o:oraov1|ORAOV1]]|0.625|
|[[:human genes:p:polr3h|POLR3H]]|0.621|
|[[:human genes:b:bap1|BAP1]]|0.621|
|[[:human genes:c:csnk2b|CSNK2B]]|0.621|
|[[:human genes:e:eif4e|EIF4E]]|0.611|
|[[:human genes:a:alg13|ALG13]]|0.608|
|[[:human genes:t:triap1|TRIAP1]]|0.607|
|[[:human genes:d:dhps|DHPS]]|0.602|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.601|
|[[:human genes:n:nars|NARS]]|0.601|
|[[:human genes:p:pelo|PELO]]|0.597|
|[[:human genes:a:aars|AARS]]|0.597|
|[[:human genes:c:ccdc101|CCDC101]]|0.597|
|[[:human genes:m:mtor|MTOR]]|0.597|
|[[:human genes:t:trnt1|TRNT1]]|0.593|
|[[:human genes:s:srp72|SRP72]]|0.593|
|[[:human genes:a:alg2|ALG2]]|0.591|
|[[:human genes:n:nae1|NAE1]]|0.591|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.59|
|[[:human genes:t:tti2|TTI2]]|0.59|
|[[:human genes:t:tti1|TTI1]]|0.59|
|[[:human genes:a:alg5|ALG5]]|0.589|
|[[:human genes:a:adsl|ADSL]]|0.589|
|[[:human genes:r:rpp21|RPP21]]|0.587|
|[[:human genes:u:uhrf1|UHRF1]]|0.577|
|[[:human genes:u:uap1|UAP1]]|0.577|
|[[:human genes:a:atp5j|ATP5J]]|0.576|
|[[:human genes:w:wdr24|WDR24]]|0.574|
|[[:human genes:s:srp68|SRP68]]|0.574|
|[[:human genes:h:hars|HARS]]|0.573|
|[[:human genes:t:tsen54|TSEN54]]|0.573|
|[[:human genes:a:atxn10|ATXN10]]|0.572|
|[[:human genes:c:cct7|CCT7]]|0.572|
|[[:human genes:p:pam16|PAM16]]|0.571|
|[[:human genes:e:exoc4|EXOC4]]|0.57|
|[[:human genes:t:tgs1|TGS1]]|0.569|
|[[:human genes:d:dad1|DAD1]]|0.568|
|[[:human genes:v:vezt|VEZT]]|0.568|
|[[:human genes:e:eprs|EPRS]]|0.565|
|[[:human genes:y:yars|YARS]]|0.565|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.565|
|[[:human genes:c:cbfb|CBFB]]|0.564|
|[[:human genes:m:mars|MARS]]|0.563|
|[[:human genes:m:meaf6|MEAF6]]|0.561|
|[[:human genes:s:srp14|SRP14]]|0.56|
|[[:human genes:o:osgep|OSGEP]]|0.559|
|[[:human genes:e:eny2|ENY2]]|0.557|
|[[:human genes:h:haus8|HAUS8]]|0.553|
|[[:human genes:p:polr3b|POLR3B]]|0.552|
|[[:human genes:d:ddx20|DDX20]]|0.551|
|[[:human genes:u:utp23|UTP23]]|0.551|
|[[:human genes:u:ube2g2|UBE2G2]]|0.55|
|[[:human genes:u:uxt|UXT]]|0.548|
|[[:human genes:r:rpn1|RPN1]]|0.548|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.542|
|[[:human genes:m:mapk14|MAPK14]]|0.538|
|[[:human genes:e:exoc3|EXOC3]]|0.538|
|[[:human genes:d:dhdds|DHDDS]]|0.531|
|[[:human genes:s:slc35b1|SLC35B1]]|0.527|
|[[:human genes:m:med23|MED23]]|0.526|
|[[:human genes:t:telo2|TELO2]]|0.525|
|[[:human genes:s:sec61g|SEC61G]]|0.525|
|[[:human genes:t:timm22|TIMM22]]|0.524|
|[[:human genes:n:nsd1|NSD1]]|0.518|
|[[:human genes:m:mllt1|MLLT1]]|0.517|
|[[:human genes:c:casp9|CASP9]]|0.517|
|[[:human genes:t:timm13|TIMM13]]|0.517|
|[[:human genes:c:crcp|CRCP]]|0.515|
|[[:human genes:z:znf259|ZNF259]]|0.514|
|[[:human genes:v:vrk1|VRK1]]|0.513|
|[[:human genes:t:trmt5|TRMT5]]|0.513|
|[[:human genes:p:plaa|PLAA]]|0.511|
|[[:human genes:z:zfx|ZFX]]|0.511|
|[[:human genes:f:faf2|FAF2]]|0.511|
|[[:human genes:v:vmp1|VMP1]]|0.51|
|[[:human genes:b:bub3|BUB3]]|0.509|
|[[:human genes:d:ddost|DDOST]]|0.509|
|[[:human genes:a:alg14|ALG14]]|0.509|
|[[:human genes:t:tmem41b|TMEM41B]]|0.508|
|[[:human genes:t:tbca|TBCA]]|0.507|
|[[:human genes:f:fnta|FNTA]]|0.505|
|[[:human genes:o:otud5|OTUD5]]|0.505|
|[[:human genes:c:cdipt|CDIPT]]|0.505|
|[[:human genes:p:ppa2|PPA2]]|0.505|
|[[:human genes:a:atp5o|ATP5O]]|0.503|
|[[:human genes:s:seh1l|SEH1L]]|0.502|
|[[:human genes:s:spcs2|SPCS2]]|0.501|
|[[:human genes:t:tsen34|TSEN34]]|0.501|
|[[:human genes:d:dnajc3|DNAJC3]]|0.5|
|[[:human genes:t:taz|TAZ]]|0.5|
|[[:human genes:t:trmt10a|TRMT10A]]|0.499|
|[[:human genes:u:uba3|UBA3]]|0.498|
|[[:human genes:t:ttc4|TTC4]]|0.496|
|[[:human genes:p:phb|PHB]]|0.494|
|[[:human genes:m:med4|MED4]]|0.494|
|[[:human genes:h:hccs|HCCS]]|0.491|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.489|
|[[:human genes:w:wars|WARS]]|0.488|
|[[:human genes:v:vhl|VHL]]|0.486|
|[[:human genes:d:dr1|DR1]]|0.486|
|[[:human genes:t:tamm41|TAMM41]]|0.485|
|[[:human genes:c:cars|CARS]]|0.485|
|[[:human genes:l:lsm11|LSM11]]|0.485|
|[[:human genes:l:lsmd1|LSMD1]]|0.483|
|[[:human genes:n:nsmce1|NSMCE1]]|0.483|
|[[:human genes:p:ppcs|PPCS]]|0.482|
|[[:human genes:a:atp5b|ATP5B]]|0.482|
|[[:human genes:g:gemin5|GEMIN5]]|0.481|
|[[:human genes:t:thoc6|THOC6]]|0.48|
|[[:human genes:s:shoc2|SHOC2]]|0.478|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.478|
|[[:human genes:c:cmtr1|CMTR1]]|0.477|
|[[:human genes:m:mad2l1|MAD2L1]]|0.477|
|[[:human genes:t:trim28|TRIM28]]|0.476|
|[[:human genes:z:zrsr2|ZRSR2]]|0.475|
|[[:human genes:w:wdr59|WDR59]]|0.474|
|[[:human genes:a:apaf1|APAF1]]|0.474|
|[[:human genes:t:txnrd1|TXNRD1]]|0.473|
|[[:human genes:k:kdsr|KDSR]]|0.472|
|[[:human genes:x:xpo6|XPO6]]|0.472|
|[[:human genes:e:elac2|ELAC2]]|0.472|
|[[:human genes:p:pisd|PISD]]|0.472|
|[[:human genes:t:txnl4b|TXNL4B]]|0.471|
|[[:human genes:e:eef1e1|EEF1E1]]|0.47|
|[[:human genes:s:sdha|SDHA]]|0.47|
|[[:human genes:b:bak1|BAK1]]|0.468|
|[[:human genes:f:fli1|FLI1]]|0.467|
|[[:human genes:a:atp2a2|ATP2A2]]|0.466|
|[[:human genes:s:snapc5|SNAPC5]]|0.466|
|[[:human genes:s:ssbp2|SSBP2]]|0.465|
|[[:human genes:p:ppp4c|PPP4C]]|0.465|
|[[:human genes:g:gpn2|GPN2]]|0.464|
|[[:human genes:s:sox7|SOX7]]|0.464|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.463|
|[[:human genes:s:spcs3|SPCS3]]|0.462|
|[[:human genes:d:ddx55|DDX55]]|0.462|
|[[:human genes:d:dkc1|DKC1]]|0.46|
|[[:human genes:c:cep350|CEP350]]|0.459|
|[[:human genes:n:naf1|NAF1]]|0.458|
|[[:human genes:d:dctn6|DCTN6]]|0.458|
|[[:human genes:u:ube2k|UBE2K]]|0.458|
|[[:human genes:g:gtf3a|GTF3A]]|0.456|
|[[:human genes:r:rbm14|RBM14]]|0.456|
|[[:human genes:t:thoc3|THOC3]]|0.455|
|[[:human genes:d:dolk|DOLK]]|0.455|
|[[:human genes:e:eno1|ENO1]]|0.454|
|[[:human genes:d:dhx29|DHX29]]|0.454|
|[[:human genes:e:eif3f|EIF3F]]|0.453|
|[[:human genes:t:tbp|TBP]]|0.453|
|[[:human genes:r:rad1|RAD1]]|0.452|
|[[:human genes:t:tprkb|TPRKB]]|0.452|
|[[:human genes:x:xpot|XPOT]]|0.451|
|[[:human genes:p:pik3r4|PIK3R4]]|0.45|
|[[:human genes:r:romo1|ROMO1]]|0.449|
|[[:human genes:p:pdap1|PDAP1]]|0.449|
|[[:human genes:h:hmgb2|HMGB2]]|0.449|
|[[:human genes:q:qars|QARS]]|0.448|
|[[:human genes:l:lmo2|LMO2]]|0.447|
|[[:human genes:t:ten1|TEN1]]|0.446|
|[[:human genes:w:wdr82|WDR82]]|0.445|
|[[:human genes:g:gemin6|GEMIN6]]|0.445|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.444|
|[[:human genes:r:rpe|RPE]]|0.443|
|[[:human genes:a:actr10|ACTR10]]|0.443|
|[[:human genes:t:tmed10|TMED10]]|0.442|
|[[:human genes:a:alg6|ALG6]]|0.442|
|[[:human genes:g:gemin8|GEMIN8]]|0.441|
|[[:human genes:c:chchd4|CHCHD4]]|0.44|
|[[:human genes:o:oip5|OIP5]]|0.44|
|[[:human genes:d:dnajb11|DNAJB11]]|0.439|
|[[:human genes:s:ssb|SSB]]|0.439|
|[[:human genes:s:snf8|SNF8]]|0.439|
|[[:human genes:t:tle4|TLE4]]|0.438|
|[[:human genes:t:tbcd|TBCD]]|0.437|
|[[:human genes:w:wdr92|WDR92]]|0.437|
|[[:human genes:d:dpf2|DPF2]]|0.436|
|[[:human genes:c:cycs|CYCS]]|0.436|
|[[:human genes:a:abcf1|ABCF1]]|0.435|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.434|
|[[:human genes:n:nupl2|NUPL2]]|0.434|
|[[:human genes:m:max|MAX]]|0.433|
|[[:human genes:s:slc25a26|SLC25A26]]|0.433|
|[[:human genes:a:abcb7|ABCB7]]|0.432|
|[[:human genes:p:polr3c|POLR3C]]|0.432|
|[[:human genes:p:pggt1b|PGGT1B]]|0.432|
|[[:human genes:m:maml1|MAML1]]|0.432|
|[[:human genes:u:ube2j1|UBE2J1]]|0.43|
|[[:human genes:p:ptchd3|PTCHD3]]|0.43|
|[[:human genes:i:id3|ID3]]|0.429|
|[[:human genes:a:asxl2|ASXL2]]|0.429|
|[[:human genes:u:ube2m|UBE2M]]|0.428|
|[[:human genes:m:mbtps2|MBTPS2]]|0.427|
|[[:human genes:z:zbtb11|ZBTB11]]|0.424|
|[[:human genes:a:ago2|AGO2]]|0.424|
|[[:human genes:k:kif14|KIF14]]|0.423|
|[[:human genes:n:nxt1|NXT1]]|0.423|
|[[:human genes:a:atf7ip|ATF7IP]]|0.423|
|[[:human genes:c:crls1|CRLS1]]|0.422|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.422|
|[[:human genes:d:dctn5|DCTN5]]|0.42|
|[[:human genes:d:dicer1|DICER1]]|0.42|
|[[:human genes:s:srprb|SRPRB]]|0.42|
|[[:human genes:c:chordc1|CHORDC1]]|0.42|
|[[:human genes:a:atp5h|ATP5H]]|0.419|
|[[:human genes:e:ercc2|ERCC2]]|0.416|
|[[:human genes:u:ube2l3|UBE2L3]]|0.415|
|[[:human genes:g:gtf2h3|GTF2H3]]|0.415|
|[[:human genes:d:derl2|DERL2]]|0.414|
|[[:human genes:p:psmg4|PSMG4]]|0.414|
|[[:human genes:t:taf1a|TAF1A]]|0.413|
|[[:human genes:w:wdr1|WDR1]]|0.413|
|[[:human genes:z:zzz3|ZZZ3]]|0.413|
|[[:human genes:d:derl1|DERL1]]|0.412|
|[[:human genes:c:cep57|CEP57]]|0.412|
|[[:human genes:a:atp5d|ATP5D]]|0.411|
|[[:human genes:s:sec62|SEC62]]|0.411|
|[[:human genes:r:rfk|RFK]]|0.411|
|[[:human genes:t:tbcb|TBCB]]|0.411|
|[[:human genes:e:eif1ax|EIF1AX]]|0.41|
|[[:human genes:e:elp3|ELP3]]|0.41|
|[[:human genes:r:rft1|RFT1]]|0.408|
|[[:human genes:v:vps41|VPS41]]|0.408|
|[[:human genes:g:gfer|GFER]]|0.408|
|[[:human genes:g:gabpa|GABPA]]|0.407|
|[[:human genes:a:atp5a1|ATP5A1]]|0.406|
|[[:human genes:u:ubqln1|UBQLN1]]|0.405|
|[[:human genes:c:cbx3|CBX3]]|0.405|
|[[:human genes:c:cops8|COPS8]]|0.404|
|[[:human genes:l:lsm10|LSM10]]|0.404|
|[[:human genes:r:rabif|RABIF]]|0.403|
|[[:human genes:c:c21orf59|C21orf59]]|0.401|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.401|
|[[:human genes:z:zbtb44|ZBTB44]]|0.401|
|[[:human genes:s:smarcd1|SMARCD1]]|0.401|
|[[:human genes:a:arih1|ARIH1]]|0.401|
|[[:human genes:e:elf2|ELF2]]|0.4|
|[[:human genes:s:sugt1|SUGT1]]|0.4|
Global Fraction of Cell Lines Where Essential: 591/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|27/28|
|bone|24/25|
|breast|23/33|
|central nervous system|50/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|12/15|
|kidney|17/21|
|liver|17/20|
|lung|62/75|
|lymphocyte|12/14|
|ovary|22/26|
|pancreas|22/24|
|peripheral nervous system|10/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|25/29|
|uterus|2/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 1512
* **Expression level (log2 read counts)**: 6.37
{{:chemogenomics:nalm6 dist.png?nolink |}}