======= RNMTL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRM3
  * **<color #00a2e8>Official Name</color>**: mitochondrial rRNA methyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55178|55178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC36|Q9HC36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNMTL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNMTL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SpoU sub bind|
|SpoU methylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (guanosine-2-O-)-methyltransferase activity|
|rRNA 2-O-methylation|
|rRNA methylation|
|rRNA modification|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.37|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl45|MRPL45]]|0.577|
|[[:human genes:f:ftsj2|FTSJ2]]|0.54|
|[[:human genes:m:mrpl3|MRPL3]]|0.532|
|[[:human genes:p:pet112|PET112]]|0.529|
|[[:human genes:m:mrpl23|MRPL23]]|0.529|
|[[:human genes:m:mrpl21|MRPL21]]|0.522|
|[[:human genes:m:mtif2|MTIF2]]|0.52|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.519|
|[[:human genes:y:yars2|YARS2]]|0.514|
|[[:human genes:a:aars2|AARS2]]|0.512|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.511|
|[[:human genes:w:wbscr16|WBSCR16]]|0.51|
|[[:human genes:p:pars2|PARS2]]|0.508|
|[[:human genes:m:mrps21|MRPS21]]|0.507|
|[[:human genes:n:ndufa1|NDUFA1]]|0.505|
|[[:human genes:m:mtg2|MTG2]]|0.503|
|[[:human genes:m:mrps35|MRPS35]]|0.502|
|[[:human genes:n:nars2|NARS2]]|0.502|
|[[:human genes:c:cars2|CARS2]]|0.501|
|[[:human genes:c:coq2|COQ2]]|0.5|
|[[:human genes:l:lars2|LARS2]]|0.499|
|[[:human genes:g:grsf1|GRSF1]]|0.499|
|[[:human genes:m:mrp63|MRP63]]|0.497|
|[[:human genes:v:vars2|VARS2]]|0.496|
|[[:human genes:r:rpusd3|RPUSD3]]|0.495|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.492|
|[[:human genes:t:trub2|TRUB2]]|0.49|
|[[:human genes:m:mrpl53|MRPL53]]|0.489|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.488|
|[[:human genes:q:qrsl1|QRSL1]]|0.486|
|[[:human genes:m:mrps6|MRPS6]]|0.481|
|[[:human genes:r:rpusd4|RPUSD4]]|0.481|
|[[:human genes:m:mrpl47|MRPL47]]|0.477|
|[[:human genes:m:mrps26|MRPS26]]|0.477|
|[[:human genes:t:timm17a|TIMM17A]]|0.476|
|[[:human genes:m:mars2|MARS2]]|0.475|
|[[:human genes:m:mterfd2|MTERFD2]]|0.474|
|[[:human genes:i:ict1|ICT1]]|0.474|
|[[:human genes:t:tars2|TARS2]]|0.474|
|[[:human genes:n:ndufa3|NDUFA3]]|0.473|
|[[:human genes:n:ndufb11|NDUFB11]]|0.472|
|[[:human genes:m:mrps23|MRPS23]]|0.471|
|[[:human genes:n:ndufa2|NDUFA2]]|0.469|
|[[:human genes:g:gfm1|GFM1]]|0.469|
|[[:human genes:e:eral1|ERAL1]]|0.467|
|[[:human genes:n:ndufc2|NDUFC2]]|0.466|
|[[:human genes:t:tfb1m|TFB1M]]|0.466|
|[[:human genes:m:mrpl15|MRPL15]]|0.465|
|[[:human genes:m:mrps16|MRPS16]]|0.464|
|[[:human genes:m:mrps25|MRPS25]]|0.464|
|[[:human genes:m:mettl17|METTL17]]|0.463|
|[[:human genes:m:mrpl17|MRPL17]]|0.462|
|[[:human genes:f:fastkd2|FASTKD2]]|0.461|
|[[:human genes:g:gfm2|GFM2]]|0.457|
|[[:human genes:d:dap3|DAP3]]|0.456|
|[[:human genes:r:rars2|RARS2]]|0.454|
|[[:human genes:m:malsu1|MALSU1]]|0.453|
|[[:human genes:n:ndufb4|NDUFB4]]|0.451|
|[[:human genes:p:polg2|POLG2]]|0.45|
|[[:human genes:m:mrps5|MRPS5]]|0.449|
|[[:human genes:n:nsun4|NSUN4]]|0.447|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.446|
|[[:human genes:d:dars2|DARS2]]|0.445|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.445|
|[[:human genes:a:atp5sl|ATP5SL]]|0.444|
|[[:human genes:m:mrps27|MRPS27]]|0.444|
|[[:human genes:p:pet117|PET117]]|0.444|
|[[:human genes:n:ndufs1|NDUFS1]]|0.443|
|[[:human genes:m:mrpl1|MRPL1]]|0.443|
|[[:human genes:n:ndufb9|NDUFB9]]|0.443|
|[[:human genes:m:mrps12|MRPS12]]|0.443|
|[[:human genes:g:gatc|GATC]]|0.443|
|[[:human genes:m:mrps14|MRPS14]]|0.442|
|[[:human genes:e:ears2|EARS2]]|0.442|
|[[:human genes:m:mrpl11|MRPL11]]|0.441|
|[[:human genes:n:ndufa11|NDUFA11]]|0.439|
|[[:human genes:p:pdss1|PDSS1]]|0.438|
|[[:human genes:c:c1qbp|C1QBP]]|0.436|
|[[:human genes:m:mtg1|MTG1]]|0.435|
|[[:human genes:a:acad9|ACAD9]]|0.435|
|[[:human genes:d:ddx28|DDX28]]|0.435|
|[[:human genes:c:chchd1|CHCHD1]]|0.434|
|[[:human genes:c:coa3|COA3]]|0.433|
|[[:human genes:n:ndufb6|NDUFB6]]|0.432|
|[[:human genes:p:pdss2|PDSS2]]|0.432|
|[[:human genes:m:mrps9|MRPS9]]|0.43|
|[[:human genes:m:mrps33|MRPS33]]|0.429|
|[[:human genes:m:mrpl20|MRPL20]]|0.429|
|[[:human genes:s:selrc1|SELRC1]]|0.429|
|[[:human genes:n:ndufb10|NDUFB10]]|0.428|
|[[:human genes:m:mrps24|MRPS24]]|0.427|
|[[:human genes:t:tefm|TEFM]]|0.426|
|[[:human genes:r:rbfa|RBFA]]|0.426|
|[[:human genes:m:mrps7|MRPS7]]|0.425|
|[[:human genes:n:ndufb7|NDUFB7]]|0.425|
|[[:human genes:m:mrpl43|MRPL43]]|0.425|
|[[:human genes:m:mrps34|MRPS34]]|0.423|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.423|
|[[:human genes:t:tomm20|TOMM20]]|0.422|
|[[:human genes:t:timm8b|TIMM8B]]|0.42|
|[[:human genes:e:ecsit|ECSIT]]|0.42|
|[[:human genes:a:aifm1|AIFM1]]|0.417|
|[[:human genes:c:cox16|COX16]]|0.417|
|[[:human genes:m:mrps22|MRPS22]]|0.416|
|[[:human genes:n:ndufs2|NDUFS2]]|0.416|
|[[:human genes:m:mrps10|MRPS10]]|0.414|
|[[:human genes:n:ndufa13|NDUFA13]]|0.414|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.412|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.412|
|[[:human genes:m:mrps18a|MRPS18A]]|0.412|
|[[:human genes:w:wars2|WARS2]]|0.411|
|[[:human genes:m:mterfd1|MTERFD1]]|0.41|
|[[:human genes:m:mrpl39|MRPL39]]|0.41|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.408|
|[[:human genes:m:mrpl42|MRPL42]]|0.407|
|[[:human genes:c:c12orf65|C12orf65]]|0.407|
|[[:human genes:n:ndufs8|NDUFS8]]|0.405|
|[[:human genes:n:ndufc1|NDUFC1]]|0.405|
|[[:human genes:s:sco2|SCO2]]|0.405|
|[[:human genes:m:mrpl2|MRPL2]]|0.404|
|[[:human genes:n:nubpl|NUBPL]]|0.403|
|[[:human genes:c:coa6|COA6]]|0.403|
|[[:human genes:s:ssbp1|SSBP1]]|0.402|
|[[:human genes:t:tufm|TUFM]]|0.402|
|[[:human genes:c:c10orf2|C10orf2]]|0.401|
|[[:human genes:m:mipep|MIPEP]]|0.4|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.4|
|[[:human genes:h:hars2|HARS2]]|0.4|
|[[:human genes:n:ndufb3|NDUFB3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNMTL1 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>