======= RPL11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL11
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6135|6135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62913|P62913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:24120868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L5 C|
|Ribosomal L5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein neddylation|
|regulation of protein neddylation|
|ubiquitin ligase inhibitor activity|
|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of ubiquitin protein ligase activity|
|5S rRNA binding|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of ubiquitin protein ligase activity|
|positive regulation of signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|ribosomal large subunit assembly|
|polysomal ribosome|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of ubiquitin-protein transferase activity|
|negative regulation of proteasomal protein catabolic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|ribosome assembly|
|cytosolic large ribosomal subunit|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|ribosomal large subunit biogenesis|
|negative regulation of protein ubiquitination|
|cytoplasmic translation|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|positive regulation of protein binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|viral gene expression|
|negative regulation of protein catabolic process|
|protein localization to endoplasmic reticulum|
|translational initiation|
|regulation of ubiquitin-dependent protein catabolic process|
|protein targeting to membrane|
|regulation of intrinsic apoptotic signaling pathway|
|protein localization to nucleus|
|structural constituent of ribosome|
|positive regulation of apoptotic signaling pathway|
|protein stabilization|
|positive regulation of binding|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|nuclear-transcribed mRNA catabolic process|
|regulation of protein ubiquitination|
|rRNA processing|
|mRNA catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|rRNA metabolic process|
|regulation of protein modification by small protein conjugation or removal|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|establishment of protein localization to membrane|
|negative regulation of transferase activity|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|ribosome biogenesis|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|regulation of binding|
|translation|
|ncRNA processing|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mRNA metabolic process|
|positive regulation of cell death|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|intracellular protein transport|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.7|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.73|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.74|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.77|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.77|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.81|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.82|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.84|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.88|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.9|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.92|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.94|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.96|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.96|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.97|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.98|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.98|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.02|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.08|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.08|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.08|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.09|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.14|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.14|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.17|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.17|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.17|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.24|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.25|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.29|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.34|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.42|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.46|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.49|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.53|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.6|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.62|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.64|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.69|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.72|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.75|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.03|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.12|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.51|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|4.33|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|4.93|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|5.91|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|7.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:heatr3|HEATR3]]|0.666|
|[[:human genes:r:rpl5|RPL5]]|0.59|
|[[:human genes:g:gtf3a|GTF3A]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL11 Expression in NALM6 Cells: 9.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>