======= RPL13A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL13A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L13a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23521|23521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40429|P40429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL13A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL13A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of formation of translation preinitiation complex|
|negative regulation of cytoplasmic translational initiation|
|regulation of formation of translation preinitiation complex|
|GAIT complex|
|regulation of cytoplasmic translational initiation|
|large ribosomal subunit|
|negative regulation of cytoplasmic translation|
|negative regulation of translational initiation|
|regulation of cytoplasmic translation|
|ribosome|
|cytosolic large ribosomal subunit|
|regulation of translational initiation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|negative regulation of translation|
|negative regulation of protein complex assembly|
|protein localization to endoplasmic reticulum|
|translational initiation|
|negative regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|protein targeting to membrane|
|mRNA binding|
|cellular response to interferon-gamma|
|structural constituent of ribosome|
|response to interferon-gamma|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of protein complex assembly|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|innate immune response|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular macromolecule catabolic process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.94|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.92|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.83|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.77|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.74|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.73|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.75|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.85|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.93|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.08|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.453|
|[[:human genes:p:polr2j3|POLR2J3]]|0.431|
|[[:human genes:r:rpl17|RPL17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL13A Expression in NALM6 Cells: 9.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>