======= RPL23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL23
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9349|9349]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62829|P62829]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603662|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to actinomycin D|
|ribosomal protein import into nucleus|
|response to actinomycin D|
|ubiquitin ligase inhibitor activity|
|large ribosomal subunit rRNA binding|
|negative regulation of ubiquitin protein ligase activity|
|negative regulation of ubiquitin-protein transferase activity|
|transcription coactivator binding|
|protein-DNA complex disassembly|
|regulation of ubiquitin protein ligase activity|
|positive regulation of signal transduction by p53 class mediator|
|negative regulation of cell cycle arrest|
|ribosome|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of ubiquitin-protein transferase activity|
|cytosolic large ribosomal subunit|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|positive regulation of cell cycle arrest|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|protein import into nucleus|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|regulation of cell cycle arrest|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|import into nucleus|
|viral transcription|
|cellular response to antibiotic|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|negative regulation of protein catabolic process|
|protein localization to endoplasmic reticulum|
|protein import|
|translational initiation|
|regulation of ubiquitin-dependent protein catabolic process|
|protein targeting to membrane|
|protein localization to nucleus|
|structural constituent of ribosome|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|nuclear-transcribed mRNA catabolic process|
|regulation of protein ubiquitination|
|mRNA catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|RNA catabolic process|
|regulation of cellular protein catabolic process|
|postsynaptic density|
|negative regulation of cellular catabolic process|
|nucleocytoplasmic transport|
|establishment of protein localization to membrane|
|nuclear transport|
|negative regulation of transferase activity|
|positive regulation of cell cycle process|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|response to antibiotic|
|negative regulation of catabolic process|
|negative regulation of cell cycle process|
|cellular response to peptide|
|negative regulation of proteolysis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|translation|
|regulation of protein catabolic process|
|cellular component disassembly|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|response to peptide|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cell cycle process|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.16|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.1|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.02|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.96|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.93|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.87|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.76|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.8|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.83|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.84|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.85|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.12|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.25|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.26|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.32|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.506|
|[[:human genes:p:prim1|PRIM1]]|0.453|
|[[:human genes:r:rpl23a|RPL23A]]|0.435|
|[[:human genes:r:rpl17|RPL17]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL23 Expression in NALM6 Cells: 9.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>