======= RPP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPP14
  * **<color #00a2e8>Official Name</color>**: ribonuclease P/MRP subunit p14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11102|11102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95059|O95059]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase P Rpp14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multimeric ribonuclease P complex|
|ribonuclease P RNA binding|
|ribonuclease P activity|
|tRNA 5-leader removal|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ncRNA processing|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 501/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|16/28|
|bone|18/26|
|breast|18/33|
|central nervous system|41/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|15/21|
|liver|14/20|
|lung|55/75|
|lymphocyte|12/16|
|ovary|15/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1195
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPP14 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>