======= RPS10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS10
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6204|6204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46783|P46783]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603632|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 40S ribosomal subunit.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S10 plectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit assembly|
|ribosome|
|cytosolic small ribosomal subunit|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.95|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.72|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.8|
|[[:results:exp303|39°C R06 exp303]]|1.89|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.06|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.533|
|[[:human genes:r:rrp7a|RRP7A]]|0.466|
|[[:human genes:r:rps12|RPS12]]|0.465|
|[[:human genes:c:chd4|CHD4]]|0.465|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:t:tceb3c|TCEB3C]]|0.451|
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.446|
|[[:human genes:r:rps5|RPS5]]|0.441|
|[[:human genes:c:ccna2|CCNA2]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.438|
|[[:human genes:e:exosc4|EXOSC4]]|0.424|
|[[:human genes:p:psmc5|PSMC5]]|0.424|
|[[:human genes:e:eif3g|EIF3G]]|0.422|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.415|
|[[:human genes:p:psmb4|PSMB4]]|0.414|
|[[:human genes:r:rps2|RPS2]]|0.412|
|[[:human genes:e:exosc9|EXOSC9]]|0.411|
|[[:human genes:p:pola1|POLA1]]|0.409|
|[[:human genes:t:trappc11|TRAPPC11]]|0.408|
|[[:human genes:s:sec13|SEC13]]|0.407|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.407|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.407|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.407|
|[[:human genes:r:rps21|RPS21]]|0.406|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.406|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.406|
|[[:human genes:n:ngdn|NGDN]]|0.405|
|[[:human genes:r:rplp1|RPLP1]]|0.404|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.403|
|[[:human genes:u:utp3|UTP3]]|0.401|
|[[:human genes:c:cln6|CLN6]]|0.4|
|[[:human genes:n:napa|NAPA]]|0.4|
|[[:human genes:c:c3orf17|C3orf17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS10 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>