======= RPS14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS14
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6208|6208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62263|P62263]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|small ribosomal subunit rRNA binding|
|translation regulator activity|
|ribosomal small subunit assembly|
|mRNA 5-UTR binding|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cytosolic small ribosomal subunit|
|maturation of SSU-rRNA|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|myeloid cell homeostasis|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|homeostasis of number of cells|
|rRNA processing|
|mRNA catabolic process|
|myeloid cell differentiation|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.54|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.93|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.88|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.7|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.7|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.7|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.7|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.73|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.78|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.82|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.93|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.96|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.99|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.02|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.15|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.2|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.25|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.485|
|[[:human genes:r:rrn3|RRN3]]|0.48|
|[[:human genes:n:nip7|NIP7]]|0.479|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.477|
|[[:human genes:r:rps16|RPS16]]|0.472|
|[[:human genes:p:psmd11|PSMD11]]|0.47|
|[[:human genes:v:vasn|VASN]]|0.465|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.463|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.463|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.458|
|[[:human genes:r:rps28|RPS28]]|0.457|
|[[:human genes:r:rps3a|RPS3A]]|0.454|
|[[:human genes:c:cope|COPE]]|0.454|
|[[:human genes:t:terf2|TERF2]]|0.453|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.45|
|[[:human genes:p:plcg2|PLCG2]]|0.45|
|[[:human genes:e:exosc5|EXOSC5]]|0.45|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.449|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.449|
|[[:human genes:a:akirin2|AKIRIN2]]|0.448|
|[[:human genes:s:syt9|SYT9]]|0.446|
|[[:human genes:o:ogfr|OGFR]]|0.444|
|[[:human genes:s:sec13|SEC13]]|0.443|
|[[:human genes:c:c14orf93|C14orf93]]|0.44|
|[[:human genes:o:orc1|ORC1]]|0.439|
|[[:human genes:c:cdc73|CDC73]]|0.439|
|[[:human genes:r:rps2|RPS2]]|0.438|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.437|
|[[:human genes:l:lrr1|LRR1]]|0.436|
|[[:human genes:r:rps5|RPS5]]|0.434|
|[[:human genes:r:rps12|RPS12]]|0.433|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.432|
|[[:human genes:r:rpl30|RPL30]]|0.43|
|[[:human genes:t:tfip11|TFIP11]]|0.43|
|[[:human genes:s:supt6h|SUPT6H]]|0.43|
|[[:human genes:p:psmb4|PSMB4]]|0.429|
|[[:human genes:c:cmya5|CMYA5]]|0.429|
|[[:human genes:c:ccna2|CCNA2]]|0.425|
|[[:human genes:p:polr2d|POLR2D]]|0.425|
|[[:human genes:s:smg7|SMG7]]|0.422|
|[[:human genes:w:wdr87|WDR87]]|0.421|
|[[:human genes:c:ccdc94|CCDC94]]|0.421|
|[[:human genes:a:ankle2|ANKLE2]]|0.42|
|[[:human genes:r:rbm39|RBM39]]|0.42|
|[[:human genes:a:adrm1|ADRM1]]|0.418|
|[[:human genes:t:top1mt|TOP1MT]]|0.418|
|[[:human genes:p:psma6|PSMA6]]|0.417|
|[[:human genes:z:zfand5|ZFAND5]]|0.415|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.415|
|[[:human genes:r:rpl14|RPL14]]|0.415|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:m:myo1h|MYO1H]]|0.413|
|[[:human genes:s:sel1l|SEL1L]]|0.41|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.41|
|[[:human genes:c:cdc45|CDC45]]|0.409|
|[[:human genes:h:hap1|HAP1]]|0.408|
|[[:human genes:s:smg1|SMG1]]|0.407|
|[[:human genes:a:arcn1|ARCN1]]|0.406|
|[[:human genes:s:scaf1|SCAF1]]|0.406|
|[[:human genes:t:traip|TRAIP]]|0.405|
|[[:human genes:t:tspy1|TSPY1]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.404|
|[[:human genes:o:orc6|ORC6]]|0.402|
|[[:human genes:r:rps3|RPS3]]|0.401|
|[[:human genes:r:rps19|RPS19]]|0.401|
|[[:human genes:p:psap|PSAP]]|0.401|
|[[:human genes:i:iscu|ISCU]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 666/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|27/28|
|bone|20/26|
|breast|32/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|17/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS14 Expression in NALM6 Cells: 8.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>