======= RPS16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS16
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6217|6217]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62249|P62249]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|small ribosomal subunit|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cytosolic small ribosomal subunit|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.75|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.7|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.73|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.75|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.75|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.78|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.91|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.99|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.02|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.05|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.07|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.11|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.14|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.44|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps3a|RPS3A]]|0.519|
|[[:human genes:a:adrm1|ADRM1]]|0.51|
|[[:human genes:r:rps5|RPS5]]|0.486|
|[[:human genes:r:rps11|RPS11]]|0.485|
|[[:human genes:r:rps3|RPS3]]|0.477|
|[[:human genes:r:rps14|RPS14]]|0.472|
|[[:human genes:r:rps28|RPS28]]|0.442|
|[[:human genes:n:nob1|NOB1]]|0.436|
|[[:human genes:r:rps7|RPS7]]|0.433|
|[[:human genes:r:rps9|RPS9]]|0.432|
|[[:human genes:r:rps12|RPS12]]|0.429|
|[[:human genes:r:rps19|RPS19]]|0.427|
|[[:human genes:r:rps27a|RPS27A]]|0.424|
|[[:human genes:c:c19orf53|C19orf53]]|0.42|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.409|
|[[:human genes:n:nip7|NIP7]]|0.408|
|[[:human genes:r:rps18|RPS18]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 66
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS16 Expression in NALM6 Cells: 8.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>