======= RPS19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS19
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6223|6223]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39019|P39019]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for pre-rRNA processing and maturation of 40S ribosomal subunits. {ECO:0000269|PubMed:16990592}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S19e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of respiratory burst involved in inflammatory response|
|negative regulation of respiratory burst involved in inflammatory response|
|regulation of respiratory burst involved in inflammatory response|
|negative regulation of respiratory burst|
|nucleolus organization|
|positive regulation of respiratory burst|
|regulation of respiratory burst|
|ribosomal small subunit assembly|
|fibroblast growth factor binding|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|monocyte chemotaxis|
|ribosome|
|cytosolic small ribosomal subunit|
|maturation of SSU-rRNA|
|mononuclear cell migration|
|disruption of cells of other organism|
|killing of cells of other organism|
|negative regulation of innate immune response|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|erythrocyte differentiation|
|defense response to Gram-negative bacterium|
|cell killing|
|erythrocyte homeostasis|
|negative regulation of response to biotic stimulus|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|myeloid cell homeostasis|
|protein targeting to ER|
|antimicrobial humoral response|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|negative regulation of immune effector process|
|Notch signaling pathway|
|myeloid leukocyte migration|
|viral gene expression|
|nucleus organization|
|protein localization to endoplasmic reticulum|
|negative regulation of inflammatory response|
|positive regulation of inflammatory response|
|translational initiation|
|leukocyte chemotaxis|
|negative regulation of immune response|
|protein tetramerization|
|modification of morphology or physiology of other organism|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|homeostasis of number of cells|
|negative regulation of defense response|
|cell chemotaxis|
|rRNA processing|
|negative regulation of multi-organism process|
|mRNA catabolic process|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|defense response to bacterium|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|humoral immune response|
|protein targeting|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|nucleobase-containing compound catabolic process|
|leukocyte migration|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|hemopoiesis|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|response to bacterium|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|positive regulation of immune response|
|RNA processing|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cell development|
|defense response to other organism|
|cell migration|
|intracellular protein transport|
|regulation of cellular component movement|
|macromolecule catabolic process|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.16|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.93|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.88|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.86|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.86|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.73|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.9|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.91|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.91|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.94|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.98|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.02|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.02|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.11|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.12|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.13|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.17|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps12|RPS12]]|0.542|
|[[:human genes:m:mt1e|MT1E]]|0.522|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.503|
|[[:human genes:g:golga8o|GOLGA8O]]|0.495|
|[[:human genes:p:psmb4|PSMB4]]|0.492|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.49|
|[[:human genes:t:tceb3c|TCEB3C]]|0.476|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.474|
|[[:human genes:c:chd4|CHD4]]|0.474|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.474|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.474|
|[[:human genes:r:rps3a|RPS3A]]|0.472|
|[[:human genes:r:rrp7a|RRP7A]]|0.472|
|[[:human genes:r:rbbp5|RBBP5]]|0.467|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.465|
|[[:human genes:n:npipb5|NPIPB5]]|0.465|
|[[:human genes:p:psmd11|PSMD11]]|0.464|
|[[:human genes:p:pan3|PAN3]]|0.464|
|[[:human genes:o:orc1|ORC1]]|0.461|
|[[:human genes:b:bysl|BYSL]]|0.459|
|[[:human genes:c:copg1|COPG1]]|0.455|
|[[:human genes:r:rps5|RPS5]]|0.454|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.453|
|[[:human genes:a:aamp|AAMP]]|0.453|
|[[:human genes:d:ddtl|DDTL]]|0.453|
|[[:human genes:p:psmb1|PSMB1]]|0.452|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.452|
|[[:human genes:l:lrr1|LRR1]]|0.451|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.451|
|[[:human genes:p:prim1|PRIM1]]|0.446|
|[[:human genes:p:psmd1|PSMD1]]|0.446|
|[[:human genes:a:aatf|AATF]]|0.445|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.445|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:c:c14orf93|C14orf93]]|0.444|
|[[:human genes:b:brd2|BRD2]]|0.444|
|[[:human genes:d:disp2|DISP2]]|0.443|
|[[:human genes:c:chchd3|CHCHD3]]|0.443|
|[[:human genes:x:xylt2|XYLT2]]|0.443|
|[[:human genes:p:pan2|PAN2]]|0.443|
|[[:human genes:g:gar1|GAR1]]|0.441|
|[[:human genes:p:paf1|PAF1]]|0.439|
|[[:human genes:v:vasn|VASN]]|0.439|
|[[:human genes:p:psmb2|PSMB2]]|0.437|
|[[:human genes:p:polr2j3|POLR2J3]]|0.437|
|[[:human genes:i:ik|IK]]|0.435|
|[[:human genes:g:gid4|GID4]]|0.433|
|[[:human genes:k:kctd17|KCTD17]]|0.432|
|[[:human genes:c:chaf1a|CHAF1A]]|0.431|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.43|
|[[:human genes:p:pola1|POLA1]]|0.429|
|[[:human genes:a:arcn1|ARCN1]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.427|
|[[:human genes:c:cope|COPE]]|0.427|
|[[:human genes:r:rpl30|RPL30]]|0.427|
|[[:human genes:r:rps16|RPS16]]|0.427|
|[[:human genes:a:adrm1|ADRM1]]|0.426|
|[[:human genes:o:orc6|ORC6]]|0.426|
|[[:human genes:c:cbwd3|CBWD3]]|0.426|
|[[:human genes:t:taf1|TAF1]]|0.426|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.423|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.42|
|[[:human genes:r:rpl6|RPL6]]|0.42|
|[[:human genes:r:rrm1|RRM1]]|0.419|
|[[:human genes:t:tspy8|TSPY8]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:n:narfl|NARFL]]|0.419|
|[[:human genes:s:sf3a3|SF3A3]]|0.418|
|[[:human genes:k:kif3c|KIF3C]]|0.418|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.417|
|[[:human genes:p:psmc2|PSMC2]]|0.417|
|[[:human genes:i:iscu|ISCU]]|0.416|
|[[:human genes:c:cdt1|CDT1]]|0.416|
|[[:human genes:d:ddx56|DDX56]]|0.415|
|[[:human genes:a:akirin2|AKIRIN2]]|0.414|
|[[:human genes:i:ints5|INTS5]]|0.413|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.412|
|[[:human genes:s:snrpa1|SNRPA1]]|0.412|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:c:ccna2|CCNA2]]|0.412|
|[[:human genes:d:ddt|DDT]]|0.412|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.412|
|[[:human genes:s:supt5h|SUPT5H]]|0.411|
|[[:human genes:n:ncl|NCL]]|0.41|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.409|
|[[:human genes:e:eif4a3|EIF4A3]]|0.409|
|[[:human genes:e:exosc9|EXOSC9]]|0.408|
|[[:human genes:r:rpl7a|RPL7A]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.407|
|[[:human genes:c:cbwd5|CBWD5]]|0.406|
|[[:human genes:v:vps54|VPS54]]|0.404|
|[[:human genes:n:noc4l|NOC4L]]|0.404|
|[[:human genes:e:eif3g|EIF3G]]|0.403|
|[[:human genes:s:sult1a3|SULT1A3]]|0.403|
|[[:human genes:t:tsg101|TSG101]]|0.403|
|[[:human genes:s:sult1a4|SULT1A4]]|0.403|
|[[:human genes:p:pdcd11|PDCD11]]|0.402|
|[[:human genes:d:dtl|DTL]]|0.402|
|[[:human genes:r:rps14|RPS14]]|0.401|
|[[:human genes:f:fam25b|FAM25B]]|0.401|
|[[:human genes:a:ankle1|ANKLE1]]|0.401|
|[[:human genes:f:fcn2|FCN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS19 Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>