======= RPS23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS23
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6228|6228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62266|P62266]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603683|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:28257692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of translational fidelity|
|stress granule assembly|
|polysomal ribosome|
|ribosome|
|cytosolic small ribosomal subunit|
|rough endoplasmic reticulum|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|synapse|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.01|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.01|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.95|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.75|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.91|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.09|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.22|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.471|
|[[:human genes:r:rps27a|RPS27A]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 391/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|16/28|
|bone|16/26|
|breast|21/33|
|central nervous system|40/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|11/21|
|liver|9/20|
|lung|35/75|
|lymphocyte|8/16|
|ovary|13/26|
|pancreas|5/24|
|peripheral nervous system|8/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|16/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS23 Expression in NALM6 Cells: 8.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>