======= RPS27L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS27L
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S27 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51065|51065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q71UM5|Q71UM5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS27L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS27L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S27e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation activator activity|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|ribosomal small subunit assembly|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|cytosolic small ribosomal subunit|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|DNA damage response, signal transduction by p53 class mediator|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|signal transduction by p53 class mediator|
|positive regulation of translation|
|DNA damage checkpoint|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cellular amide metabolic process|
|positive regulation of cysteine-type endopeptidase activity|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|structural constituent of ribosome|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cell cycle phase transition|
|ribonucleoprotein complex assembly|
|regulation of cysteine-type endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|apoptotic signaling pathway|
|ribosome biogenesis|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of translation|
|positive regulation of proteolysis|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cell cycle process|
|organelle assembly|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|regulation of hydrolase activity|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3793
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS27L Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>