======= RPS5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS5
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6193|6193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46782|P46782]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit assembly|
|regulation of translational fidelity|
|rRNA binding|
|cytosolic small ribosomal subunit|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|ribonucleoprotein complex|
|protein targeting to membrane|
|mRNA binding|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.7|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.71|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.8|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.83|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.91|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.07|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.18|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps3a|RPS3A]]|0.55|
|[[:human genes:r:rbbp5|RBBP5]]|0.545|
|[[:human genes:r:rps28|RPS28]]|0.538|
|[[:human genes:r:rps12|RPS12]]|0.535|
|[[:human genes:r:rps11|RPS11]]|0.534|
|[[:human genes:c:cdc6|CDC6]]|0.528|
|[[:human genes:r:rps2|RPS2]]|0.523|
|[[:human genes:t:tfip11|TFIP11]]|0.521|
|[[:human genes:p:psmb4|PSMB4]]|0.52|
|[[:human genes:r:rpl35|RPL35]]|0.51|
|[[:human genes:c:c14orf93|C14orf93]]|0.5|
|[[:human genes:p:psmb2|PSMB2]]|0.499|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.498|
|[[:human genes:p:polr2j3|POLR2J3]]|0.495|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.494|
|[[:human genes:c:ccna2|CCNA2]]|0.493|
|[[:human genes:c:cbwd5|CBWD5]]|0.487|
|[[:human genes:t:tceb3c|TCEB3C]]|0.486|
|[[:human genes:r:rps16|RPS16]]|0.486|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.485|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.483|
|[[:human genes:m:myb|MYB]]|0.483|
|[[:human genes:r:rrp7a|RRP7A]]|0.482|
|[[:human genes:p:pola1|POLA1]]|0.482|
|[[:human genes:p:psmc5|PSMC5]]|0.482|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.479|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.479|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.479|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.479|
|[[:human genes:h:hivep3|HIVEP3]]|0.479|
|[[:human genes:d:ddx56|DDX56]]|0.478|
|[[:human genes:c:cbwd3|CBWD3]]|0.477|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.476|
|[[:human genes:b:bysl|BYSL]]|0.475|
|[[:human genes:a:acsf2|ACSF2]]|0.47|
|[[:human genes:p:psmb1|PSMB1]]|0.468|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.465|
|[[:human genes:c:chd4|CHD4]]|0.464|
|[[:human genes:g:golga8o|GOLGA8O]]|0.462|
|[[:human genes:i:iscu|ISCU]]|0.462|
|[[:human genes:u:utp20|UTP20]]|0.461|
|[[:human genes:s:supt5h|SUPT5H]]|0.46|
|[[:human genes:r:riok2|RIOK2]]|0.459|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.459|
|[[:human genes:v:vasn|VASN]]|0.457|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.456|
|[[:human genes:r:rps7|RPS7]]|0.456|
|[[:human genes:r:rps19|RPS19]]|0.454|
|[[:human genes:c:cbwd6|CBWD6]]|0.454|
|[[:human genes:p:psmc1|PSMC1]]|0.454|
|[[:human genes:c:chaf1a|CHAF1A]]|0.454|
|[[:human genes:c:cdc73|CDC73]]|0.453|
|[[:human genes:p:pola2|POLA2]]|0.452|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.451|
|[[:human genes:c:cwc22|CWC22]]|0.45|
|[[:human genes:a:abhd8|ABHD8]]|0.45|
|[[:human genes:r:rps6|RPS6]]|0.448|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.448|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:r:rps9|RPS9]]|0.445|
|[[:human genes:s:sf3a1|SF3A1]]|0.445|
|[[:human genes:p:psma1|PSMA1]]|0.445|
|[[:human genes:p:psma7|PSMA7]]|0.445|
|[[:human genes:n:noc4l|NOC4L]]|0.444|
|[[:human genes:p:pwp2|PWP2]]|0.443|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.442|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.442|
|[[:human genes:r:rps10|RPS10]]|0.441|
|[[:human genes:p:psmd6|PSMD6]]|0.44|
|[[:human genes:n:npipb8|NPIPB8]]|0.44|
|[[:human genes:p:psmc2|PSMC2]]|0.437|
|[[:human genes:c:ccdc116|CCDC116]]|0.435|
|[[:human genes:k:krt78|KRT78]]|0.435|
|[[:human genes:s:sf3a3|SF3A3]]|0.435|
|[[:human genes:r:rps14|RPS14]]|0.434|
|[[:human genes:e:exosc5|EXOSC5]]|0.433|
|[[:human genes:n:npipb5|NPIPB5]]|0.433|
|[[:human genes:c:ckap5|CKAP5]]|0.432|
|[[:human genes:c:cdc45|CDC45]]|0.432|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.432|
|[[:human genes:s:s1pr4|S1PR4]]|0.43|
|[[:human genes:r:rpl14|RPL14]]|0.43|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.429|
|[[:human genes:t:ticrr|TICRR]]|0.429|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.427|
|[[:human genes:n:nupl1|NUPL1]]|0.427|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.427|
|[[:human genes:a:aqr|AQR]]|0.427|
|[[:human genes:s:supt6h|SUPT6H]]|0.426|
|[[:human genes:n:nob1|NOB1]]|0.425|
|[[:human genes:h:heatr1|HEATR1]]|0.425|
|[[:human genes:p:psmd3|PSMD3]]|0.425|
|[[:human genes:t:tsg101|TSG101]]|0.424|
|[[:human genes:r:rpl30|RPL30]]|0.424|
|[[:human genes:r:rpl6|RPL6]]|0.424|
|[[:human genes:l:lad1|LAD1]]|0.423|
|[[:human genes:m:mdm2|MDM2]]|0.423|
|[[:human genes:o:orc1|ORC1]]|0.423|
|[[:human genes:p:ppan|PPAN]]|0.421|
|[[:human genes:p:psmc6|PSMC6]]|0.421|
|[[:human genes:s:slc4a1|SLC4A1]]|0.421|
|[[:human genes:o:orc6|ORC6]]|0.42|
|[[:human genes:c:chchd3|CHCHD3]]|0.419|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.417|
|[[:human genes:p:psmd1|PSMD1]]|0.417|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:s:sap30bp|SAP30BP]]|0.416|
|[[:human genes:h:hap1|HAP1]]|0.415|
|[[:human genes:k:krt2|KRT2]]|0.414|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.414|
|[[:human genes:i:ints5|INTS5]]|0.413|
|[[:human genes:k:kif3c|KIF3C]]|0.413|
|[[:human genes:e:exosc1|EXOSC1]]|0.411|
|[[:human genes:r:rps8|RPS8]]|0.411|
|[[:human genes:r:rpl9|RPL9]]|0.41|
|[[:human genes:n:nup133|NUP133]]|0.41|
|[[:human genes:n:nol12|NOL12]]|0.41|
|[[:human genes:u:utp3|UTP3]]|0.409|
|[[:human genes:m:mt1e|MT1E]]|0.409|
|[[:human genes:a:adrm1|ADRM1]]|0.409|
|[[:human genes:c:copg1|COPG1]]|0.409|
|[[:human genes:n:ncapg|NCAPG]]|0.409|
|[[:human genes:c:col2a1|COL2A1]]|0.409|
|[[:human genes:g:golga8j|GOLGA8J]]|0.408|
|[[:human genes:o:osbp|OSBP]]|0.408|
|[[:human genes:p:pan2|PAN2]]|0.408|
|[[:human genes:z:znf830|ZNF830]]|0.408|
|[[:human genes:a:ankle2|ANKLE2]]|0.408|
|[[:human genes:t:tpx2|TPX2]]|0.407|
|[[:human genes:p:pole|POLE]]|0.407|
|[[:human genes:c:cope|COPE]]|0.407|
|[[:human genes:t:twistnb|TWISTNB]]|0.407|
|[[:human genes:z:znf574|ZNF574]]|0.406|
|[[:human genes:n:nsf|NSF]]|0.406|
|[[:human genes:e:eif4a3|EIF4A3]]|0.405|
|[[:human genes:a:ahctf1|AHCTF1]]|0.405|
|[[:human genes:c:cactin|CACTIN]]|0.404|
|[[:human genes:d:dido1|DIDO1]]|0.404|
|[[:human genes:u:utp6|UTP6]]|0.404|
|[[:human genes:n:nup98|NUP98]]|0.404|
|[[:human genes:t:taf15|TAF15]]|0.404|
|[[:human genes:c:cep192|CEP192]]|0.404|
|[[:human genes:x:xab2|XAB2]]|0.403|
|[[:human genes:i:incenp|INCENP]]|0.403|
|[[:human genes:c:c3orf17|C3orf17]]|0.403|
|[[:human genes:b:brd2|BRD2]]|0.403|
|[[:human genes:c:cmya5|CMYA5]]|0.402|
|[[:human genes:u:uqcrh|UQCRH]]|0.402|
|[[:human genes:p:paf1|PAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 318/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|7/28|
|bone|17/26|
|breast|12/33|
|central nervous system|24/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|10/21|
|liver|4/20|
|lung|34/75|
|lymphocyte|7/16|
|ovary|14/26|
|pancreas|10/24|
|peripheral nervous system|10/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS5 Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>