======= RRP15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRP15
  * **<color #00a2e8>Official Name</color>**: ribosomal RNA processing 15 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51018|51018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3B9|Q9Y3B9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRP15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRP15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611193|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rrp15p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.7|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.72|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.8|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.88|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.93|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.95|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.96|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.12|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.25|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.68|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrn3|RRN3]]|0.514|
|[[:human genes:n:nol12|NOL12]]|0.508|
|[[:human genes:p:psmb4|PSMB4]]|0.501|
|[[:human genes:m:myo1h|MYO1H]]|0.494|
|[[:human genes:c:cep192|CEP192]]|0.493|
|[[:human genes:p:psmc6|PSMC6]]|0.492|
|[[:human genes:s:supt6h|SUPT6H]]|0.492|
|[[:human genes:p:psmd1|PSMD1]]|0.489|
|[[:human genes:p:pole|POLE]]|0.489|
|[[:human genes:a:arcn1|ARCN1]]|0.487|
|[[:human genes:p:psmd3|PSMD3]]|0.486|
|[[:human genes:s:snrpa1|SNRPA1]]|0.48|
|[[:human genes:c:cactin|CACTIN]]|0.479|
|[[:human genes:c:cdc6|CDC6]]|0.479|
|[[:human genes:t:tfip11|TFIP11]]|0.477|
|[[:human genes:s:slc4a1|SLC4A1]]|0.477|
|[[:human genes:s:stil|STIL]]|0.475|
|[[:human genes:s:syt9|SYT9]]|0.474|
|[[:human genes:c:cdc45|CDC45]]|0.474|
|[[:human genes:c:cope|COPE]]|0.471|
|[[:human genes:d:ddtl|DDTL]]|0.471|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.47|
|[[:human genes:n:nol10|NOL10]]|0.468|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.467|
|[[:human genes:p:pola2|POLA2]]|0.467|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.467|
|[[:human genes:c:ckap5|CKAP5]]|0.466|
|[[:human genes:m:mt1e|MT1E]]|0.464|
|[[:human genes:p:psma6|PSMA6]]|0.462|
|[[:human genes:c:cbwd6|CBWD6]]|0.461|
|[[:human genes:h:hap1|HAP1]]|0.46|
|[[:human genes:n:nupl1|NUPL1]]|0.46|
|[[:human genes:n:narfl|NARFL]]|0.459|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.459|
|[[:human genes:p:paf1|PAF1]]|0.459|
|[[:human genes:p:psmd2|PSMD2]]|0.459|
|[[:human genes:c:ccdc94|CCDC94]]|0.458|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.458|
|[[:human genes:c:chd4|CHD4]]|0.458|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.457|
|[[:human genes:r:rbm39|RBM39]]|0.456|
|[[:human genes:c:copb1|COPB1]]|0.456|
|[[:human genes:o:orc6|ORC6]]|0.455|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.455|
|[[:human genes:c:cbwd3|CBWD3]]|0.454|
|[[:human genes:t:tceb3c|TCEB3C]]|0.454|
|[[:human genes:c:cbwd5|CBWD5]]|0.454|
|[[:human genes:s:sf3a2|SF3A2]]|0.453|
|[[:human genes:a:aqr|AQR]]|0.453|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.452|
|[[:human genes:d:dtl|DTL]]|0.452|
|[[:human genes:t:ticrr|TICRR]]|0.452|
|[[:human genes:d:dock6|DOCK6]]|0.451|
|[[:human genes:r:rpl35|RPL35]]|0.451|
|[[:human genes:n:nup43|NUP43]]|0.451|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.45|
|[[:human genes:v:vasn|VASN]]|0.45|
|[[:human genes:r:rpl15|RPL15]]|0.45|
|[[:human genes:p:psmd6|PSMD6]]|0.45|
|[[:human genes:c:copb2|COPB2]]|0.449|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.449|
|[[:human genes:r:rps2|RPS2]]|0.448|
|[[:human genes:s:snrnp200|SNRNP200]]|0.448|
|[[:human genes:p:psmb2|PSMB2]]|0.448|
|[[:human genes:m:myb|MYB]]|0.448|
|[[:human genes:p:psmc1|PSMC1]]|0.447|
|[[:human genes:w:wdr43|WDR43]]|0.447|
|[[:human genes:f:fam160a1|FAM160A1]]|0.446|
|[[:human genes:r:rpl9|RPL9]]|0.445|
|[[:human genes:o:orc1|ORC1]]|0.444|
|[[:human genes:n:nbpf10|NBPF10]]|0.443|
|[[:human genes:r:rpl34|RPL34]]|0.443|
|[[:human genes:s:sart1|SART1]]|0.443|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.443|
|[[:human genes:d:ddt|DDT]]|0.443|
|[[:human genes:r:rad51|RAD51]]|0.442|
|[[:human genes:g:golga8j|GOLGA8J]]|0.441|
|[[:human genes:m:myh2|MYH2]]|0.44|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.44|
|[[:human genes:c:cdc73|CDC73]]|0.44|
|[[:human genes:c:chmp2a|CHMP2A]]|0.439|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.439|
|[[:human genes:b:bysl|BYSL]]|0.439|
|[[:human genes:s:ssh2|SSH2]]|0.438|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.438|
|[[:human genes:c:ccna2|CCNA2]]|0.438|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.438|
|[[:human genes:c:copg1|COPG1]]|0.437|
|[[:human genes:c:ctage4|CTAGE4]]|0.436|
|[[:human genes:t:tspy1|TSPY1]]|0.434|
|[[:human genes:r:rpl14|RPL14]]|0.434|
|[[:human genes:a:ankle2|ANKLE2]]|0.434|
|[[:human genes:r:rad21|RAD21]]|0.434|
|[[:human genes:p:psmb3|PSMB3]]|0.433|
|[[:human genes:m:mtch2|MTCH2]]|0.432|
|[[:human genes:t:tspy8|TSPY8]]|0.431|
|[[:human genes:o:osbp|OSBP]]|0.43|
|[[:human genes:p:psma7|PSMA7]]|0.43|
|[[:human genes:r:rpl6|RPL6]]|0.429|
|[[:human genes:c:cdc5l|CDC5L]]|0.429|
|[[:human genes:f:fam25b|FAM25B]]|0.427|
|[[:human genes:c:cgb2|CGB2]]|0.427|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.427|
|[[:human genes:n:npipb5|NPIPB5]]|0.427|
|[[:human genes:k:krt78|KRT78]]|0.426|
|[[:human genes:s:sf3a3|SF3A3]]|0.426|
|[[:human genes:t:tyms|TYMS]]|0.426|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:p:polr2j3|POLR2J3]]|0.425|
|[[:human genes:r:rps9|RPS9]]|0.425|
|[[:human genes:m:med17|MED17]]|0.424|
|[[:human genes:u:utp3|UTP3]]|0.423|
|[[:human genes:r:rrp1|RRP1]]|0.423|
|[[:human genes:d:ddx56|DDX56]]|0.423|
|[[:human genes:e:esf1|ESF1]]|0.423|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.422|
|[[:human genes:a:ahctf1|AHCTF1]]|0.422|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.422|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.422|
|[[:human genes:n:nbpf16|NBPF16]]|0.42|
|[[:human genes:s:slc6a17|SLC6A17]]|0.42|
|[[:human genes:n:nol6|NOL6]]|0.42|
|[[:human genes:z:zfand5|ZFAND5]]|0.42|
|[[:human genes:r:rpl26|RPL26]]|0.42|
|[[:human genes:m:mki67ip|MKI67IP]]|0.419|
|[[:human genes:z:znf541|ZNF541]]|0.419|
|[[:human genes:m:mcoln1|MCOLN1]]|0.419|
|[[:human genes:c:cdca3|CDCA3]]|0.419|
|[[:human genes:c:copz1|COPZ1]]|0.419|
|[[:human genes:g:gprin2|GPRIN2]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.418|
|[[:human genes:r:rnf113a|RNF113A]]|0.417|
|[[:human genes:z:znf655|ZNF655]]|0.417|
|[[:human genes:t:twistnb|TWISTNB]]|0.417|
|[[:human genes:p:polr2a|POLR2A]]|0.416|
|[[:human genes:p:plrg1|PLRG1]]|0.416|
|[[:human genes:k:krt13|KRT13]]|0.415|
|[[:human genes:s:sap30bp|SAP30BP]]|0.414|
|[[:human genes:a:aamp|AAMP]]|0.414|
|[[:human genes:n:nip7|NIP7]]|0.413|
|[[:human genes:r:rpl38|RPL38]]|0.413|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.412|
|[[:human genes:p:pbxip1|PBXIP1]]|0.412|
|[[:human genes:r:ranbp2|RANBP2]]|0.412|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.412|
|[[:human genes:p:psmc2|PSMC2]]|0.412|
|[[:human genes:a:acsf2|ACSF2]]|0.411|
|[[:human genes:t:trim52|TRIM52]]|0.411|
|[[:human genes:m:mbtd1|MBTD1]]|0.41|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.41|
|[[:human genes:i:ik|IK]]|0.41|
|[[:human genes:c:chaf1a|CHAF1A]]|0.41|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.409|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.409|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.409|
|[[:human genes:e:exosc3|EXOSC3]]|0.408|
|[[:human genes:r:rrs1|RRS1]]|0.408|
|[[:human genes:e:exosc9|EXOSC9]]|0.408|
|[[:human genes:n:nol8|NOL8]]|0.408|
|[[:human genes:u:upf1|UPF1]]|0.407|
|[[:human genes:i:igfn1|IGFN1]]|0.406|
|[[:human genes:b:brd2|BRD2]]|0.406|
|[[:human genes:r:rfxank|RFXANK]]|0.406|
|[[:human genes:r:riok2|RIOK2]]|0.405|
|[[:human genes:d:dhx38|DHX38]]|0.404|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.404|
|[[:human genes:p:psmc5|PSMC5]]|0.404|
|[[:human genes:z:znf675|ZNF675]]|0.404|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.403|
|[[:human genes:c:cwc22|CWC22]]|0.403|
|[[:human genes:t:tagln|TAGLN]]|0.403|
|[[:human genes:p:psmc4|PSMC4]]|0.402|
|[[:human genes:r:rpl30|RPL30]]|0.402|
|[[:human genes:r:rbbp5|RBBP5]]|0.402|
|[[:human genes:w:wdr75|WDR75]]|0.402|
|[[:human genes:s:snrpb|SNRPB]]|0.401|
|[[:human genes:c:c14orf93|C14orf93]]|0.401|
|[[:human genes:g:gosr2|GOSR2]]|0.401|
|[[:human genes:z:znf830|ZNF830]]|0.4|
|[[:human genes:d:dhfr|DHFR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 190/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|8/28|
|bone|8/26|
|breast|5/33|
|central nervous system|20/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|8/21|
|liver|1/20|
|lung|15/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|12/24|
|peripheral nervous system|5/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRP15 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>