======= RSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSF1
  * **<color #00a2e8>Official Name</color>**: remodeling and spacing factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51773|51773]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96T23|Q96T23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RSF complex|
|nucleosome positioning|
|histone acetyltransferase complex|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|positive regulation of viral transcription|
|histone exchange|
|histone acetyltransferase activity|
|negative regulation of DNA binding|
|regulation of viral transcription|
|ATP-dependent chromatin remodeling|
|positive regulation of viral process|
|histone acetylation|
|nucleosome assembly|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of DNA binding|
|histone binding|
|chromatin assembly|
|protein acetylation|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|negative regulation of binding|
|DNA packaging|
|protein acylation|
|protein-DNA complex assembly|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ATPase activity|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|DNA conformation change|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of multi-organism process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|regulation of multi-organism process|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.8|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.74|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.77|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.86|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.87|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.89|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.89|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.96|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.1|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.14|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.21|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.35|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.41|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.41|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.473|
|[[:human genes:z:znf148|ZNF148]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSF1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>