======= RSPO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSPO2
  * **<color #00a2e8>Official Name</color>**: R-spondin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340419|340419]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXX9|Q6UXX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSPO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSPO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of odontogenesis of dentin-containing tooth|
|negative regulation of odontogenesis|
|trachea cartilage morphogenesis|
|lung growth|
|trachea cartilage development|
|trachea morphogenesis|
|regulation of odontogenesis of dentin-containing tooth|
|trachea development|
|epithelial tube branching involved in lung morphogenesis|
|regulation of odontogenesis|
|embryonic hindlimb morphogenesis|
|cartilage morphogenesis|
|dopaminergic neuron differentiation|
|embryonic forelimb morphogenesis|
|negative regulation of animal organ morphogenesis|
|hindlimb morphogenesis|
|frizzled binding|
|forelimb morphogenesis|
|lung morphogenesis|
|bone mineralization|
|biomineral tissue development|
|biomineralization|
|organ growth|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|osteoblast differentiation|
|branching morphogenesis of an epithelial tube|
|positive regulation of canonical Wnt signaling pathway|
|appendage morphogenesis|
|limb morphogenesis|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|heparin binding|
|cartilage development|
|respiratory tube development|
|positive regulation of Wnt signaling pathway|
|limb development|
|appendage development|
|respiratory system development|
|connective tissue development|
|regulation of animal organ morphogenesis|
|ossification|
|regulation of canonical Wnt signaling pathway|
|epithelial tube morphogenesis|
|signaling receptor binding|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|developmental growth|
|growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|skeletal system development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cell surface|
|tube morphogenesis|
|tube development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|generation of neurons|
|extracellular space|
|neurogenesis|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.72|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.19|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8541
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSPO2 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>