======= RTKN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTKN
  * **<color #00a2e8>Official Name</color>**: rhotekin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6242|6242]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BST9|Q9BST9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RTKN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RTKN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602288|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|HR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to mitotic actomyosin contractile ring|
|protein localization to actomyosin contractile ring|
|septin ring organization|
|protein localization to cell division site|
|protein localization to actin cytoskeleton|
|septin cytoskeleton organization|
|actomyosin contractile ring|
|protein localization to cell cortex|
|assembly of actomyosin apparatus involved in cytokinesis|
|actomyosin contractile ring assembly|
|actomyosin contractile ring organization|
|GTPase inhibitor activity|
|GTP-Rho binding|
|cytokinetic process|
|protein localization to cytoskeleton|
|cortical actin cytoskeleton organization|
|negative regulation of GTPase activity|
|cortical cytoskeleton organization|
|mitotic cytokinesis|
|Rho protein signal transduction|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|actomyosin structure organization|
|protein localization to cell periphery|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTP binding|
|cellular component|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|cell division|
|actin cytoskeleton organization|
|actin filament-based process|
|mitotic cell cycle process|
|mitotic cell cycle|
|protein localization to organelle|
|negative regulation of catalytic activity|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RTKN Expression in NALM6 Cells: 2.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>