======= RTN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTN4
  * **<color #00a2e8>Official Name</color>**: reticulon 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57142|57142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQC3|Q9NQC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RTN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RTN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Reticulon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ERBB3 signaling pathway|
|regulation of ERBB3 signaling pathway|
|positive regulation of protein localization to endoplasmic reticulum|
|regulation of protein localization to endoplasmic reticulum|
|positive regulation of toll-like receptor 9 signaling pathway|
|cellular sphingolipid homeostasis|
|endoplasmic reticulum tubular network formation|
|endoplasmic reticulum tubular network membrane organization|
|regulation of branching morphogenesis of a nerve|
|endoplasmic reticulum tubular network membrane|
|positive regulation of mammary gland epithelial cell proliferation|
|regulation of toll-like receptor 9 signaling pathway|
|nuclear pore complex assembly|
|endoplasmic reticulum tubular network organization|
|endoplasmic reticulum tubular network|
|nuclear pore organization|
|regulation of mammary gland epithelial cell proliferation|
|pore complex assembly|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|neuron projection fasciculation|
|axonal fasciculation|
|positive regulation of toll-like receptor signaling pathway|
|cardiac epithelial to mesenchymal transition|
|cerebral cortex radially oriented cell migration|
|positive regulation of ERBB signaling pathway|
|glial cell migration|
|protein localization to lysosome|
|blastocyst formation|
|negative regulation of axon extension|
|cerebral cortex cell migration|
|neuron recognition|
|endoplasmic reticulum organization|
|regulation of morphogenesis of a branching structure|
|telencephalon cell migration|
|forebrain cell migration|
|protein localization to vacuole|
|regulation of toll-like receptor signaling pathway|
|negative regulation of axonogenesis|
|epithelial to mesenchymal transition|
|regulation of ERBB signaling pathway|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|cell projection|
|blastocyst development|
|negative regulation of developmental growth|
|integral component of endoplasmic reticulum membrane|
|regulation of extent of cell growth|
|cerebral cortex development|
|lipid homeostasis|
|nucleus organization|
|positive regulation of epithelial cell migration|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|positive regulation of protein kinase B signaling|
|pallium development|
|protein stabilization|
|nuclear envelope|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|gliogenesis|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of neuron differentiation|
|cell recognition|
|negative regulation of growth|
|heart morphogenesis|
|postsynaptic density|
|telencephalon development|
|regulation of protein stability|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|negative regulation of nervous system development|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|neuronal cell body|
|regulation of cellular component size|
|in utero embryonic development|
|forebrain development|
|axon development|
|regulation of cell growth|
|endomembrane system organization|
|regulation of innate immune response|
|positive regulation of defense response|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cell junction|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|brain development|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|membrane organization|
|positive regulation of immune response|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|RNA binding|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.78|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.75|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.75|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.75|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.77|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.87|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.92|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.1|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.15|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RTN4 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>