======= RXRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RXRA
  * **<color #00a2e8>Official Name</color>**: retinoid X receptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6256|6256]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19793|P19793]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RXRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RXRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:20215566}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nuc recep-AF1|
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of translational initiation by iron|
|vitamin D response element binding|
|regulation of translational initiation by iron|
|DBD domain binding|
|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|
|regulation of branching involved in prostate gland morphogenesis|
|retinoic acid-responsive element binding|
|peroxisome proliferator activated receptor signaling pathway|
|LBD domain binding|
|prostate glandular acinus development|
|epithelial cell differentiation involved in prostate gland development|
|cardiac muscle cell proliferation|
|vitamin D receptor binding|
|striated muscle cell proliferation|
|retinoic acid receptor signaling pathway|
|ventricular cardiac muscle cell differentiation|
|muscle cell proliferation|
|nuclear receptor binding|
|retinoic acid binding|
|cardiac muscle tissue growth|
|heart growth|
|bile acid and bile salt transport|
|positive regulation of translational initiation|
|modulation by virus of host morphology or physiology|
|maternal placenta development|
|embryo implantation|
|glandular epithelial cell differentiation|
|modification by symbiont of host morphology or physiology|
|prostate gland development|
|nuclear receptor activity|
|ventricular cardiac muscle tissue morphogenesis|
|peptide binding|
|steroid hormone receptor activity|
|ventricular cardiac muscle tissue development|
|regulation of morphogenesis of a branching structure|
|maternal process involved in female pregnancy|
|cardiac muscle tissue morphogenesis|
|chromatin DNA binding|
|RNA polymerase II transcription factor complex|
|cardiac ventricle morphogenesis|
|regulation of translational initiation|
|muscle tissue morphogenesis|
|muscle organ morphogenesis|
|cardiac muscle cell differentiation|
|protein homotetramerization|
|columnar/cuboidal epithelial cell differentiation|
|organ growth|
|double-stranded DNA binding|
|response to retinoic acid|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|cardiocyte differentiation|
|cholesterol metabolic process|
|steroid hormone mediated signaling pathway|
|vitamin metabolic process|
|positive regulation of translation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|secondary alcohol metabolic process|
|sterol metabolic process|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|protein tetramerization|
|positive regulation of cellular amide metabolic process|
|placenta development|
|modification of morphology or physiology of other organism|
|interaction with host|
|regulation of reproductive process|
|cardiac muscle tissue development|
|intracellular receptor signaling pathway|
|cardiac chamber development|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|female pregnancy|
|regulation of morphogenesis of an epithelium|
|cellular response to steroid hormone stimulus|
|striated muscle cell differentiation|
|signaling receptor activity|
|receptor complex|
|multi-multicellular organism process|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|muscle cell differentiation|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|steroid metabolic process|
|transcription coactivator activity|
|striated muscle tissue development|
|organic acid transport|
|carboxylic acid transport|
|muscle organ development|
|muscle tissue development|
|lipid transport|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|alcohol metabolic process|
|urogenital system development|
|lipid localization|
|response to steroid hormone|
|protein homooligomerization|
|response to acid chemical|
|enzyme binding|
|regulation of translation|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|gland development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|organic hydroxy compound metabolic process|
|organic anion transport|
|muscle structure development|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|protein complex oligomerization|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|heart development|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|anion transport|
|protein-containing complex|
|cellular response to hormone stimulus|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|zinc ion binding|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|embryo development|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.86|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.78|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.454|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RXRA Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>