======= SAFB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAFB2
  * **<color #00a2e8>Official Name</color>**: scaffold attachment factor B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9667|9667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14151|Q14151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAFB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAFB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608066|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Sertoli cell differentiation|
|regulation of androgen receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of mRNA processing|
|male sex differentiation|
|gonad development|
|development of primary sexual characteristics|
|sex differentiation|
|nuclear body|
|regulation of mRNA metabolic process|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|identical protein binding|
|epithelium development|
|RNA binding|
|reproductive process|
|reproduction|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.82|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.8|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.75|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.73|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.81|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.35|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.39|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10971
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAFB2 Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>