======= SAP30BP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAP30BP
  * **<color #00a2e8>Official Name</color>**: SAP30 binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29115|29115]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHR5|Q9UHR5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAP30BP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAP30BP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610218|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes. {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:15496587}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HCNGP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intermediate filament cytoskeleton|
|positive regulation of cell death|
|apoptotic process|
|programmed cell death|
|cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.87|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.75|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.72|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.73|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.81|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.07|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.12|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.535|
|[[:human genes:i:ik|IK]]|0.52|
|[[:human genes:a:aamp|AAMP]]|0.514|
|[[:human genes:e:exosc4|EXOSC4]]|0.492|
|[[:human genes:k:kctd17|KCTD17]]|0.491|
|[[:human genes:c:cbwd6|CBWD6]]|0.483|
|[[:human genes:p:pan3|PAN3]]|0.481|
|[[:human genes:t:tfip11|TFIP11]]|0.478|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.473|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.472|
|[[:human genes:r:rbm39|RBM39]]|0.472|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.472|
|[[:human genes:p:psmb4|PSMB4]]|0.472|
|[[:human genes:n:npipb5|NPIPB5]]|0.47|
|[[:human genes:v:vasn|VASN]]|0.466|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.465|
|[[:human genes:r:rbm22|RBM22]]|0.463|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.463|
|[[:human genes:c:cbwd3|CBWD3]]|0.462|
|[[:human genes:o:osbp|OSBP]]|0.462|
|[[:human genes:p:psmd3|PSMD3]]|0.46|
|[[:human genes:g:golga6a|GOLGA6A]]|0.457|
|[[:human genes:o:orc6|ORC6]]|0.457|
|[[:human genes:a:arcn1|ARCN1]]|0.454|
|[[:human genes:o:or10g3|OR10G3]]|0.452|
|[[:human genes:r:rps2|RPS2]]|0.45|
|[[:human genes:r:rnpc3|RNPC3]]|0.447|
|[[:human genes:t:tagln|TAGLN]]|0.445|
|[[:human genes:c:ccna2|CCNA2]]|0.445|
|[[:human genes:t:tceb3c|TCEB3C]]|0.444|
|[[:human genes:g:golga6b|GOLGA6B]]|0.444|
|[[:human genes:s:srfbp1|SRFBP1]]|0.442|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.442|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.442|
|[[:human genes:n:nfatc4|NFATC4]]|0.441|
|[[:human genes:e:exosc9|EXOSC9]]|0.441|
|[[:human genes:i:igfn1|IGFN1]]|0.441|
|[[:human genes:p:pole|POLE]]|0.44|
|[[:human genes:t:twistnb|TWISTNB]]|0.439|
|[[:human genes:c:c14orf93|C14orf93]]|0.439|
|[[:human genes:x:xylt2|XYLT2]]|0.437|
|[[:human genes:s:snrpa1|SNRPA1]]|0.436|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.433|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.433|
|[[:human genes:p:paf1|PAF1]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.431|
|[[:human genes:z:znf830|ZNF830]]|0.431|
|[[:human genes:s:sec13|SEC13]]|0.431|
|[[:human genes:p:plekha4|PLEKHA4]]|0.431|
|[[:human genes:n:narfl|NARFL]]|0.43|
|[[:human genes:c:copg1|COPG1]]|0.428|
|[[:human genes:d:ddtl|DDTL]]|0.426|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.426|
|[[:human genes:m:mfsd12|MFSD12]]|0.425|
|[[:human genes:p:prpf19|PRPF19]]|0.425|
|[[:human genes:a:acsf2|ACSF2]]|0.424|
|[[:human genes:c:col2a1|COL2A1]]|0.424|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.423|
|[[:human genes:c:cbwd5|CBWD5]]|0.422|
|[[:human genes:r:rrn3|RRN3]]|0.421|
|[[:human genes:r:rps9|RPS9]]|0.42|
|[[:human genes:c:cope|COPE]]|0.42|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.419|
|[[:human genes:c:copb1|COPB1]]|0.419|
|[[:human genes:n:nol10|NOL10]]|0.418|
|[[:human genes:s:supt5h|SUPT5H]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.417|
|[[:human genes:r:rpl35|RPL35]]|0.417|
|[[:human genes:p:polr2a|POLR2A]]|0.417|
|[[:human genes:r:rps5|RPS5]]|0.416|
|[[:human genes:m:mylk3|MYLK3]]|0.416|
|[[:human genes:n:nupl1|NUPL1]]|0.416|
|[[:human genes:r:ranbp2|RANBP2]]|0.415|
|[[:human genes:r:rrp15|RRP15]]|0.414|
|[[:human genes:c:cebpz|CEBPZ]]|0.414|
|[[:human genes:p:psmd2|PSMD2]]|0.413|
|[[:human genes:d:dtl|DTL]]|0.413|
|[[:human genes:e:exosc5|EXOSC5]]|0.412|
|[[:human genes:u:utp3|UTP3]]|0.412|
|[[:human genes:r:rps12|RPS12]]|0.412|
|[[:human genes:a:ankle2|ANKLE2]]|0.411|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.41|
|[[:human genes:z:znf148|ZNF148]]|0.41|
|[[:human genes:s:stil|STIL]]|0.408|
|[[:human genes:p:psma7|PSMA7]]|0.408|
|[[:human genes:i:itga2b|ITGA2B]]|0.408|
|[[:human genes:k:kif3c|KIF3C]]|0.407|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.407|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:r:rpl34|RPL34]]|0.405|
|[[:human genes:r:rps7|RPS7]]|0.405|
|[[:human genes:p:psmc1|PSMC1]]|0.405|
|[[:human genes:s:slc6a17|SLC6A17]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.403|
|[[:human genes:c:cactin|CACTIN]]|0.403|
|[[:human genes:c:cln6|CLN6]]|0.403|
|[[:human genes:p:plk1|PLK1]]|0.403|
|[[:human genes:g:golga8o|GOLGA8O]]|0.402|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.401|
|[[:human genes:a:aatf|AATF]]|0.401|
|[[:human genes:s:sf3a3|SF3A3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1205
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAP30BP Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>