======= SARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SARS2
  * **<color #00a2e8>Official Name</color>**: seryl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54938|54938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP81|Q9NP81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612804|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Seryl tRNA N|
|tRNA-synt 2b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|seryl-tRNA aminoacylation|
|serine-tRNA ligase activity|
|selenocysteinyl-tRNA(Sec) biosynthetic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|RNA biosynthetic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.15|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.77|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.77|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.75|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.74|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.82|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.87|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.03|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.19|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.23|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.28|
|[[:results:exp539|42°C R08 exp539]]|2.3|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.32|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.44|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.673|
|[[:human genes:m:mrps5|MRPS5]]|0.667|
|[[:human genes:s:selrc1|SELRC1]]|0.662|
|[[:human genes:m:mrps14|MRPS14]]|0.66|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.657|
|[[:human genes:m:mrpl23|MRPL23]]|0.644|
|[[:human genes:m:mrps6|MRPS6]]|0.642|
|[[:human genes:r:rpusd4|RPUSD4]]|0.64|
|[[:human genes:c:cox16|COX16]]|0.64|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.639|
|[[:human genes:b:bcs1l|BCS1L]]|0.637|
|[[:human genes:m:mrps2|MRPS2]]|0.635|
|[[:human genes:m:mrp63|MRP63]]|0.631|
|[[:human genes:m:mrpl21|MRPL21]]|0.629|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.628|
|[[:human genes:t:tars2|TARS2]]|0.625|
|[[:human genes:v:vars2|VARS2]]|0.625|
|[[:human genes:m:mrps34|MRPS34]]|0.625|
|[[:human genes:m:mrpl47|MRPL47]]|0.621|
|[[:human genes:m:mrps9|MRPS9]]|0.621|
|[[:human genes:c:cox6c|COX6C]]|0.613|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.613|
|[[:human genes:m:mrps21|MRPS21]]|0.613|
|[[:human genes:m:mrpl15|MRPL15]]|0.61|
|[[:human genes:m:mrpl53|MRPL53]]|0.609|
|[[:human genes:m:mrps18a|MRPS18A]]|0.609|
|[[:human genes:t:tufm|TUFM]]|0.607|
|[[:human genes:f:fastkd5|FASTKD5]]|0.6|
|[[:human genes:s:sco2|SCO2]]|0.6|
|[[:human genes:m:mrps16|MRPS16]]|0.6|
|[[:human genes:d:dars2|DARS2]]|0.594|
|[[:human genes:g:gfm1|GFM1]]|0.594|
|[[:human genes:d:dap3|DAP3]]|0.593|
|[[:human genes:p:pars2|PARS2]]|0.585|
|[[:human genes:e:ears2|EARS2]]|0.578|
|[[:human genes:q:qrsl1|QRSL1]]|0.577|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.576|
|[[:human genes:m:mrps26|MRPS26]]|0.574|
|[[:human genes:p:pnpt1|PNPT1]]|0.574|
|[[:human genes:m:mrpl34|MRPL34]]|0.571|
|[[:human genes:m:mrps24|MRPS24]]|0.57|
|[[:human genes:p:pdss1|PDSS1]]|0.566|
|[[:human genes:r:rbfa|RBFA]]|0.564|
|[[:human genes:c:c17orf89|C17orf89]]|0.563|
|[[:human genes:c:cox7b|COX7B]]|0.563|
|[[:human genes:s:slc25a26|SLC25A26]]|0.563|
|[[:human genes:h:hars2|HARS2]]|0.562|
|[[:human genes:c:c10orf2|C10orf2]]|0.561|
|[[:human genes:f:fars2|FARS2]]|0.559|
|[[:human genes:e:elac2|ELAC2]]|0.558|
|[[:human genes:n:ndufa3|NDUFA3]]|0.556|
|[[:human genes:m:mtg2|MTG2]]|0.55|
|[[:human genes:m:mrpl12|MRPL12]]|0.549|
|[[:human genes:c:coa3|COA3]]|0.545|
|[[:human genes:m:mrpl55|MRPL55]]|0.544|
|[[:human genes:c:cox17|COX17]]|0.544|
|[[:human genes:u:uqcr10|UQCR10]]|0.542|
|[[:human genes:m:mrps25|MRPS25]]|0.542|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.541|
|[[:human genes:n:ndufb11|NDUFB11]]|0.541|
|[[:human genes:m:mrps10|MRPS10]]|0.54|
|[[:human genes:m:mrps33|MRPS33]]|0.54|
|[[:human genes:c:c12orf65|C12orf65]]|0.534|
|[[:human genes:m:mtpap|MTPAP]]|0.531|
|[[:human genes:t:tfam|TFAM]]|0.53|
|[[:human genes:c:chchd4|CHCHD4]]|0.53|
|[[:human genes:t:tefm|TEFM]]|0.528|
|[[:human genes:c:coa6|COA6]]|0.526|
|[[:human genes:c:cox15|COX15]]|0.521|
|[[:human genes:t:trub2|TRUB2]]|0.521|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.52|
|[[:human genes:m:mrps23|MRPS23]]|0.519|
|[[:human genes:n:nars2|NARS2]]|0.519|
|[[:human genes:l:lars2|LARS2]]|0.518|
|[[:human genes:c:coa5|COA5]]|0.518|
|[[:human genes:m:mars2|MARS2]]|0.514|
|[[:human genes:g:gatc|GATC]]|0.513|
|[[:human genes:m:mrpl36|MRPL36]]|0.513|
|[[:human genes:w:wbscr16|WBSCR16]]|0.51|
|[[:human genes:m:mrps12|MRPS12]]|0.509|
|[[:human genes:t:tmem126b|TMEM126B]]|0.502|
|[[:human genes:n:ndufs7|NDUFS7]]|0.501|
|[[:human genes:g:gfm2|GFM2]]|0.498|
|[[:human genes:n:ndufb5|NDUFB5]]|0.497|
|[[:human genes:c:coq2|COQ2]]|0.497|
|[[:human genes:m:mrpl44|MRPL44]]|0.497|
|[[:human genes:m:mrpl27|MRPL27]]|0.496|
|[[:human genes:m:mrpl33|MRPL33]]|0.493|
|[[:human genes:m:mrpl20|MRPL20]]|0.491|
|[[:human genes:t:tpk1|TPK1]]|0.49|
|[[:human genes:m:mrpl4|MRPL4]]|0.486|
|[[:human genes:p:ppcs|PPCS]]|0.485|
|[[:human genes:a:aifm1|AIFM1]]|0.484|
|[[:human genes:p:polrmt|POLRMT]]|0.484|
|[[:human genes:t:tomm20|TOMM20]]|0.482|
|[[:human genes:a:atp5d|ATP5D]]|0.482|
|[[:human genes:t:triap1|TRIAP1]]|0.481|
|[[:human genes:m:mrpl18|MRPL18]]|0.48|
|[[:human genes:r:rars2|RARS2]]|0.479|
|[[:human genes:f:ftsj2|FTSJ2]]|0.478|
|[[:human genes:t:tmem242|TMEM242]]|0.477|
|[[:human genes:t:tomm22|TOMM22]]|0.476|
|[[:human genes:t:tomm40|TOMM40]]|0.476|
|[[:human genes:c:cox5a|COX5A]]|0.476|
|[[:human genes:m:mtif3|MTIF3]]|0.473|
|[[:human genes:n:ndufa2|NDUFA2]]|0.47|
|[[:human genes:m:mrpl22|MRPL22]]|0.468|
|[[:human genes:a:atp5c1|ATP5C1]]|0.468|
|[[:human genes:m:mrpl41|MRPL41]]|0.466|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.464|
|[[:human genes:c:cox6b1|COX6B1]]|0.464|
|[[:human genes:m:mrpl43|MRPL43]]|0.463|
|[[:human genes:r:rpia|RPIA]]|0.462|
|[[:human genes:m:mrpl45|MRPL45]]|0.461|
|[[:human genes:u:uap1|UAP1]]|0.461|
|[[:human genes:u:uqcrq|UQCRQ]]|0.461|
|[[:human genes:a:atp5a1|ATP5A1]]|0.46|
|[[:human genes:t:tamm41|TAMM41]]|0.459|
|[[:human genes:m:mrpl42|MRPL42]]|0.459|
|[[:human genes:p:pmm2|PMM2]]|0.459|
|[[:human genes:p:pgm3|PGM3]]|0.458|
|[[:human genes:n:ndufb3|NDUFB3]]|0.456|
|[[:human genes:m:mrps11|MRPS11]]|0.456|
|[[:human genes:d:dhrsx|DHRSX]]|0.454|
|[[:human genes:p:pet112|PET112]]|0.454|
|[[:human genes:c:coq4|COQ4]]|0.452|
|[[:human genes:f:fastkd1|FASTKD1]]|0.451|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.45|
|[[:human genes:h:hccs|HCCS]]|0.45|
|[[:human genes:c:cox7c|COX7C]]|0.449|
|[[:human genes:a:atp5b|ATP5B]]|0.449|
|[[:human genes:d:dhx30|DHX30]]|0.447|
|[[:human genes:m:mrpl39|MRPL39]]|0.446|
|[[:human genes:m:mrpl3|MRPL3]]|0.444|
|[[:human genes:p:polg2|POLG2]]|0.444|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.443|
|[[:human genes:r:rpusd3|RPUSD3]]|0.442|
|[[:human genes:u:uhrf1|UHRF1]]|0.442|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.442|
|[[:human genes:a:atp5j|ATP5J]]|0.442|
|[[:human genes:s:slc25a19|SLC25A19]]|0.441|
|[[:human genes:m:msto1|MSTO1]]|0.44|
|[[:human genes:m:mrps7|MRPS7]]|0.44|
|[[:human genes:m:mrpl32|MRPL32]]|0.44|
|[[:human genes:t:timm8b|TIMM8B]]|0.44|
|[[:human genes:t:thg1l|THG1L]]|0.439|
|[[:human genes:a:alg13|ALG13]]|0.439|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.438|
|[[:human genes:e:ecsit|ECSIT]]|0.438|
|[[:human genes:h:higd2a|HIGD2A]]|0.436|
|[[:human genes:a:aars2|AARS2]]|0.435|
|[[:human genes:m:mterfd2|MTERFD2]]|0.434|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.433|
|[[:human genes:m:mterfd1|MTERFD1]]|0.432|
|[[:human genes:p:polg|POLG]]|0.432|
|[[:human genes:l:lrpprc|LRPPRC]]|0.432|
|[[:human genes:c:coq7|COQ7]]|0.431|
|[[:human genes:s:srp14|SRP14]]|0.43|
|[[:human genes:t:tmem261|TMEM261]]|0.429|
|[[:human genes:r:rpe|RPE]]|0.428|
|[[:human genes:p:ppa2|PPA2]]|0.428|
|[[:human genes:a:atxn10|ATXN10]]|0.427|
|[[:human genes:m:mipep|MIPEP]]|0.426|
|[[:human genes:n:ndufv1|NDUFV1]]|0.425|
|[[:human genes:a:atp5sl|ATP5SL]]|0.425|
|[[:human genes:d:dpagt1|DPAGT1]]|0.425|
|[[:human genes:n:ndufc2|NDUFC2]]|0.423|
|[[:human genes:v:vezt|VEZT]]|0.422|
|[[:human genes:m:mrps17|MRPS17]]|0.422|
|[[:human genes:f:fh|FH]]|0.421|
|[[:human genes:a:atic|ATIC]]|0.42|
|[[:human genes:c:chchd1|CHCHD1]]|0.42|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:c:coq5|COQ5]]|0.418|
|[[:human genes:t:ten1|TEN1]]|0.418|
|[[:human genes:c:cycs|CYCS]]|0.417|
|[[:human genes:t:trnt1|TRNT1]]|0.416|
|[[:human genes:a:alas1|ALAS1]]|0.416|
|[[:human genes:n:ndufa1|NDUFA1]]|0.416|
|[[:human genes:s:ssb|SSB]]|0.415|
|[[:human genes:m:mrpl52|MRPL52]]|0.413|
|[[:human genes:t:taz|TAZ]]|0.413|
|[[:human genes:c:crls1|CRLS1]]|0.413|
|[[:human genes:m:mtg1|MTG1]]|0.413|
|[[:human genes:t:tmem51|TMEM51]]|0.412|
|[[:human genes:m:mrps35|MRPS35]]|0.412|
|[[:human genes:m:mrpl11|MRPL11]]|0.408|
|[[:human genes:g:gfpt1|GFPT1]]|0.407|
|[[:human genes:m:mrpl38|MRPL38]]|0.406|
|[[:human genes:a:alg8|ALG8]]|0.405|
|[[:human genes:a:alg1|ALG1]]|0.405|
|[[:human genes:c:cox11|COX11]]|0.404|
|[[:human genes:p:ptdss1|PTDSS1]]|0.402|
|[[:human genes:m:minos1|MINOS1]]|0.402|
|[[:human genes:m:mrpl9|MRPL9]]|0.401|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.401|
|[[:human genes:n:ndufb1|NDUFB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 125/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|4/28|
|bone|6/26|
|breast|7/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|5/21|
|liver|2/20|
|lung|17/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 540
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SARS2 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>