======= SCARA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCARA3
  * **<color #00a2e8>Official Name</color>**: scavenger receptor class A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51435|51435]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6AZY7|Q6AZY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCARA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCARA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602728|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. {ECO:0000269|PubMed:9580669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor 3 signaling pathway|
|complement activation, lectin pathway|
|UV protection|
|chondrocyte morphogenesis involved in endochondral bone morphogenesis|
|chondrocyte morphogenesis|
|growth plate cartilage chondrocyte morphogenesis|
|growth plate cartilage morphogenesis|
|mannose binding|
|chondrocyte development involved in endochondral bone morphogenesis|
|growth plate cartilage chondrocyte differentiation|
|cartilage morphogenesis|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|endochondral bone growth|
|chondrocyte development|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|scavenger receptor activity|
|collagen trimer|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|organ growth|
|toll-like receptor signaling pathway|
|bone morphogenesis|
|pattern recognition receptor signaling pathway|
|response to UV|
|cartilage development|
|complement activation|
|bone development|
|connective tissue development|
|extracellular matrix|
|innate immune response-activating signal transduction|
|skeletal system morphogenesis|
|activation of innate immune response|
|response to light stimulus|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|response to oxidative stress|
|developmental growth|
|growth|
|response to radiation|
|regulation of innate immune response|
|positive regulation of defense response|
|skeletal system development|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|endocytosis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|tissue morphogenesis|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|Golgi membrane|
|activation of immune response|
|import into cell|
|calcium ion binding|
|cell morphogenesis|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|cellular component morphogenesis|
|positive regulation of immune response|
|endoplasmic reticulum membrane|
|defense response to other organism|
|animal organ morphogenesis|
|endoplasmic reticulum|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|cell development|
|regulation of immune system process|
|tissue development|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCARA3 Expression in NALM6 Cells: 0.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>