======= SCEL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCEL
  * **<color #00a2e8>Official Name</color>**: sciellin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8796|8796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95171|O95171]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCEL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCEL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cornified envelope|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|response to mechanical stimulus|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|epidermal cell differentiation|
|regulation of Wnt signaling pathway|
|skin development|
|epidermis development|
|embryo development ending in birth or egg hatching|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|embryo development|
|epithelium development|
|response to abiotic stimulus|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.49|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.19|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.1|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.72|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.7|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.72|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.79|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.87|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.95|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCEL Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>