======= SCG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCG2
  * **<color #00a2e8>Official Name</color>**: secretogranin II
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7857|7857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13521|P13521]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Granin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuronal dense core vesicle|
|induction of positive chemotaxis|
|eosinophil chemotaxis|
|eosinophil migration|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|negative regulation of endothelial cell apoptotic process|
|chemoattractant activity|
|negative regulation of endothelial cell proliferation|
|negative regulation of epithelial cell apoptotic process|
|positive chemotaxis|
|regulation of endothelial cell apoptotic process|
|endothelial cell migration|
|regulation of epithelial cell apoptotic process|
|epithelial cell migration|
|epithelium migration|
|secretory granule|
|granulocyte chemotaxis|
|positive regulation of endothelial cell proliferation|
|tissue migration|
|granulocyte migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of epithelial cell proliferation|
|myeloid leukocyte migration|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|regulation of extrinsic apoptotic signaling pathway|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|ameboidal-type cell migration|
|peptide secretion|
|cytokine activity|
|positive regulation of epithelial cell proliferation|
|cell chemotaxis|
|regulation of chemotaxis|
|negative regulation of apoptotic signaling pathway|
|endoplasmic reticulum lumen|
|angiogenesis|
|regulation of epithelial cell proliferation|
|post-translational protein modification|
|MAPK cascade|
|leukocyte migration|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|blood vessel development|
|inflammatory response|
|vasculature development|
|cardiovascular system development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|secretion|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|intracellular signal transduction|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.8|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.74|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.74|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.77|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.78|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.88|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.16|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.21|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6855
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCG2 Expression in NALM6 Cells: -1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>