======= SCO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCO2
  * **<color #00a2e8>Official Name</color>**: synthesis of cytochrome C oxidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9997|9997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43819|O43819]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604272|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SCO1-SenC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transferase activity, transferring pentosyl groups|
|phosphorylase activity|
|cellular copper ion homeostasis|
|copper ion homeostasis|
|copper ion transport|
|mitochondrial respiratory chain complex IV assembly|
|protein disulfide oxidoreductase activity|
|pyrimidine nucleobase metabolic process|
|respiratory chain complex IV assembly|
|myofibril|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|pyrimidine nucleoside metabolic process|
|nucleobase metabolic process|
|copper ion binding|
|cell redox homeostasis|
|mitochondrial respiratory chain complex assembly|
|pyrimidine-containing compound metabolic process|
|cellular transition metal ion homeostasis|
|nucleoside metabolic process|
|transition metal ion transport|
|transition metal ion homeostasis|
|glycosyl compound metabolic process|
|eye development|
|visual system development|
|sensory system development|
|mitochondrial matrix|
|mitochondrial inner membrane|
|mitochondrion organization|
|nucleobase-containing small molecule metabolic process|
|sensory organ development|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|mitochondrion|
|ion transport|
|protein-containing complex assembly|
|homeostatic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.48|
|[[:results:exp303|39°C R06 exp303]]|-2.41|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.3|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.28|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.25|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.22|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.08|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.07|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.06|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.96|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.94|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.93|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.83|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.8|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.79|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.79|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.79|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.76|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.75|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.72|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.75|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.76|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.8|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.83|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.83|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.84|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.88|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.89|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.91|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.92|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.94|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.97|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.15|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.77|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.755|
|[[:human genes:y:yars2|YARS2]]|0.733|
|[[:human genes:t:tars2|TARS2]]|0.726|
|[[:human genes:b:bcs1l|BCS1L]]|0.71|
|[[:human genes:n:nars2|NARS2]]|0.704|
|[[:human genes:c:cox16|COX16]]|0.698|
|[[:human genes:g:gfm1|GFM1]]|0.694|
|[[:human genes:e:ears2|EARS2]]|0.691|
|[[:human genes:q:qrsl1|QRSL1]]|0.689|
|[[:human genes:m:mrps6|MRPS6]]|0.689|
|[[:human genes:m:mrpl21|MRPL21]]|0.685|
|[[:human genes:c:coa3|COA3]]|0.679|
|[[:human genes:d:dap3|DAP3]]|0.676|
|[[:human genes:m:mrps16|MRPS16]]|0.676|
|[[:human genes:m:mrps34|MRPS34]]|0.673|
|[[:human genes:d:dars2|DARS2]]|0.668|
|[[:human genes:v:vars2|VARS2]]|0.668|
|[[:human genes:m:mrps14|MRPS14]]|0.666|
|[[:human genes:p:pars2|PARS2]]|0.665|
|[[:human genes:f:fastkd5|FASTKD5]]|0.659|
|[[:human genes:c:cox11|COX11]]|0.655|
|[[:human genes:r:rpusd4|RPUSD4]]|0.645|
|[[:human genes:m:mrps21|MRPS21]]|0.643|
|[[:human genes:l:lars2|LARS2]]|0.638|
|[[:human genes:m:mrpl47|MRPL47]]|0.636|
|[[:human genes:c:c10orf2|C10orf2]]|0.633|
|[[:human genes:a:aars2|AARS2]]|0.633|
|[[:human genes:m:mrps26|MRPS26]]|0.629|
|[[:human genes:m:mrpl23|MRPL23]]|0.626|
|[[:human genes:r:rbfa|RBFA]]|0.625|
|[[:human genes:c:cox15|COX15]]|0.623|
|[[:human genes:m:mrpl53|MRPL53]]|0.623|
|[[:human genes:m:mrps25|MRPS25]]|0.618|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.617|
|[[:human genes:m:mrps5|MRPS5]]|0.616|
|[[:human genes:m:mrp63|MRP63]]|0.614|
|[[:human genes:m:mrps2|MRPS2]]|0.614|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.614|
|[[:human genes:p:pet112|PET112]]|0.612|
|[[:human genes:f:fars2|FARS2]]|0.612|
|[[:human genes:h:hars2|HARS2]]|0.61|
|[[:human genes:m:mtg2|MTG2]]|0.608|
|[[:human genes:c:coa6|COA6]]|0.608|
|[[:human genes:p:polg2|POLG2]]|0.602|
|[[:human genes:p:pet117|PET117]]|0.6|
|[[:human genes:s:sars2|SARS2]]|0.6|
|[[:human genes:r:rars2|RARS2]]|0.599|
|[[:human genes:g:gfm2|GFM2]]|0.598|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.597|
|[[:human genes:m:mrpl45|MRPL45]]|0.595|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.594|
|[[:human genes:w:wars2|WARS2]]|0.592|
|[[:human genes:c:cox7b|COX7B]]|0.591|
|[[:human genes:c:c12orf65|C12orf65]]|0.588|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.588|
|[[:human genes:t:tufm|TUFM]]|0.584|
|[[:human genes:m:mrps18a|MRPS18A]]|0.583|
|[[:human genes:n:ndufa3|NDUFA3]]|0.581|
|[[:human genes:g:gatc|GATC]]|0.578|
|[[:human genes:p:pgm3|PGM3]]|0.576|
|[[:human genes:s:slc25a26|SLC25A26]]|0.573|
|[[:human genes:m:mars2|MARS2]]|0.572|
|[[:human genes:a:aifm1|AIFM1]]|0.572|
|[[:human genes:m:mettl17|METTL17]]|0.567|
|[[:human genes:m:mrpl15|MRPL15]]|0.566|
|[[:human genes:a:atp5c1|ATP5C1]]|0.555|
|[[:human genes:d:dhrsx|DHRSX]]|0.555|
|[[:human genes:n:ndufb11|NDUFB11]]|0.552|
|[[:human genes:m:mrps24|MRPS24]]|0.548|
|[[:human genes:p:pnpt1|PNPT1]]|0.544|
|[[:human genes:m:mtpap|MTPAP]]|0.542|
|[[:human genes:w:wbscr16|WBSCR16]]|0.537|
|[[:human genes:t:tmem242|TMEM242]]|0.537|
|[[:human genes:c:coq2|COQ2]]|0.536|
|[[:human genes:m:mrps22|MRPS22]]|0.535|
|[[:human genes:t:tefm|TEFM]]|0.534|
|[[:human genes:m:mrpl12|MRPL12]]|0.533|
|[[:human genes:f:ftsj2|FTSJ2]]|0.532|
|[[:human genes:m:mrpl36|MRPL36]]|0.53|
|[[:human genes:m:mrps11|MRPS11]]|0.527|
|[[:human genes:n:ndufa2|NDUFA2]]|0.527|
|[[:human genes:m:mrps23|MRPS23]]|0.527|
|[[:human genes:c:cox17|COX17]]|0.526|
|[[:human genes:m:mrps12|MRPS12]]|0.525|
|[[:human genes:m:mtg1|MTG1]]|0.525|
|[[:human genes:p:pet100|PET100]]|0.523|
|[[:human genes:m:mrpl20|MRPL20]]|0.522|
|[[:human genes:c:cox20|COX20]]|0.52|
|[[:human genes:c:cox6c|COX6C]]|0.52|
|[[:human genes:m:mrps9|MRPS9]]|0.52|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.517|
|[[:human genes:p:polg|POLG]]|0.517|
|[[:human genes:t:tomm20|TOMM20]]|0.516|
|[[:human genes:t:trub2|TRUB2]]|0.516|
|[[:human genes:a:atp5a1|ATP5A1]]|0.514|
|[[:human genes:m:mrpl44|MRPL44]]|0.513|
|[[:human genes:h:higd2a|HIGD2A]]|0.512|
|[[:human genes:d:dnlz|DNLZ]]|0.511|
|[[:human genes:c:c17orf89|C17orf89]]|0.508|
|[[:human genes:m:mrps33|MRPS33]]|0.507|
|[[:human genes:p:polrmt|POLRMT]]|0.503|
|[[:human genes:m:mrpl11|MRPL11]]|0.501|
|[[:human genes:n:ndufb5|NDUFB5]]|0.5|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.499|
|[[:human genes:m:mrpl18|MRPL18]]|0.499|
|[[:human genes:r:rpia|RPIA]]|0.499|
|[[:human genes:m:mrpl3|MRPL3]]|0.498|
|[[:human genes:a:atp5d|ATP5D]]|0.498|
|[[:human genes:n:ndufs2|NDUFS2]]|0.494|
|[[:human genes:m:mrpl4|MRPL4]]|0.494|
|[[:human genes:m:mrpl42|MRPL42]]|0.493|
|[[:human genes:m:mrpl55|MRPL55]]|0.49|
|[[:human genes:u:uqcr10|UQCR10]]|0.489|
|[[:human genes:m:mrps10|MRPS10]]|0.487|
|[[:human genes:m:mterfd2|MTERFD2]]|0.487|
|[[:human genes:t:timm8b|TIMM8B]]|0.487|
|[[:human genes:c:coq7|COQ7]]|0.485|
|[[:human genes:m:mrpl34|MRPL34]]|0.483|
|[[:human genes:p:pdss1|PDSS1]]|0.482|
|[[:human genes:i:iba57|IBA57]]|0.481|
|[[:human genes:f:fh|FH]]|0.479|
|[[:human genes:c:cars2|CARS2]]|0.479|
|[[:human genes:c:coa5|COA5]]|0.477|
|[[:human genes:m:mtif3|MTIF3]]|0.476|
|[[:human genes:s:slc25a3|SLC25A3]]|0.476|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.473|
|[[:human genes:t:triap1|TRIAP1]]|0.473|
|[[:human genes:m:mrpl43|MRPL43]]|0.471|
|[[:human genes:l:lrpprc|LRPPRC]]|0.469|
|[[:human genes:c:chchd4|CHCHD4]]|0.468|
|[[:human genes:c:cox6b1|COX6B1]]|0.468|
|[[:human genes:m:mrps35|MRPS35]]|0.466|
|[[:human genes:m:mrpl2|MRPL2]]|0.466|
|[[:human genes:n:ndufc2|NDUFC2]]|0.465|
|[[:human genes:c:coq5|COQ5]]|0.464|
|[[:human genes:m:mrpl39|MRPL39]]|0.463|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.461|
|[[:human genes:r:rpusd3|RPUSD3]]|0.46|
|[[:human genes:l:lsm10|LSM10]]|0.459|
|[[:human genes:n:ndufa1|NDUFA1]]|0.457|
|[[:human genes:a:atp5b|ATP5B]]|0.456|
|[[:human genes:m:mrps27|MRPS27]]|0.455|
|[[:human genes:e:elac2|ELAC2]]|0.451|
|[[:human genes:m:malsu1|MALSU1]]|0.45|
|[[:human genes:e:ecsit|ECSIT]]|0.45|
|[[:human genes:n:nfu1|NFU1]]|0.45|
|[[:human genes:n:ndufb6|NDUFB6]]|0.45|
|[[:human genes:h:hccs|HCCS]]|0.449|
|[[:human genes:m:mipep|MIPEP]]|0.447|
|[[:human genes:m:mrpl27|MRPL27]]|0.446|
|[[:human genes:c:coq4|COQ4]]|0.446|
|[[:human genes:a:atp5o|ATP5O]]|0.445|
|[[:human genes:m:mrpl37|MRPL37]]|0.445|
|[[:human genes:t:tpk1|TPK1]]|0.445|
|[[:human genes:t:trmt61a|TRMT61A]]|0.444|
|[[:human genes:c:chchd1|CHCHD1]]|0.443|
|[[:human genes:d:dhx30|DHX30]]|0.443|
|[[:human genes:m:mrpl33|MRPL33]]|0.443|
|[[:human genes:t:tfam|TFAM]]|0.442|
|[[:human genes:d:ddx28|DDX28]]|0.442|
|[[:human genes:t:tmem126b|TMEM126B]]|0.441|
|[[:human genes:p:ptcd3|PTCD3]]|0.441|
|[[:human genes:c:c11orf57|C11orf57]]|0.44|
|[[:human genes:r:rpe|RPE]]|0.438|
|[[:human genes:a:atic|ATIC]]|0.438|
|[[:human genes:n:ndufa10|NDUFA10]]|0.437|
|[[:human genes:n:ndufv1|NDUFV1]]|0.437|
|[[:human genes:m:mrpl35|MRPL35]]|0.436|
|[[:human genes:a:atp5l|ATP5L]]|0.435|
|[[:human genes:t:tfb1m|TFB1M]]|0.435|
|[[:human genes:p:pmvk|PMVK]]|0.434|
|[[:human genes:c:cox10|COX10]]|0.433|
|[[:human genes:m:mrpl13|MRPL13]]|0.431|
|[[:human genes:s:sco1|SCO1]]|0.431|
|[[:human genes:m:mrps7|MRPS7]]|0.431|
|[[:human genes:u:uqcrq|UQCRQ]]|0.431|
|[[:human genes:n:ndufb3|NDUFB3]]|0.431|
|[[:human genes:m:mrpl22|MRPL22]]|0.429|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.429|
|[[:human genes:p:pmm2|PMM2]]|0.429|
|[[:human genes:c:coq3|COQ3]]|0.428|
|[[:human genes:m:mrpl52|MRPL52]]|0.428|
|[[:human genes:c:coq6|COQ6]]|0.427|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.424|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.424|
|[[:human genes:t:tamm41|TAMM41]]|0.423|
|[[:human genes:a:alg8|ALG8]]|0.423|
|[[:human genes:p:ppcs|PPCS]]|0.423|
|[[:human genes:n:nubpl|NUBPL]]|0.42|
|[[:human genes:n:ndufa11|NDUFA11]]|0.42|
|[[:human genes:c:cox5a|COX5A]]|0.419|
|[[:human genes:n:ndufs7|NDUFS7]]|0.417|
|[[:human genes:t:tomm6|TOMM6]]|0.417|
|[[:human genes:a:atp5e|ATP5E]]|0.416|
|[[:human genes:m:mrpl1|MRPL1]]|0.415|
|[[:human genes:z:zcrb1|ZCRB1]]|0.413|
|[[:human genes:u:uqcc2|UQCC2]]|0.413|
|[[:human genes:t:tomm40|TOMM40]]|0.413|
|[[:human genes:o:opa1|OPA1]]|0.412|
|[[:human genes:e:eral1|ERAL1]]|0.411|
|[[:human genes:n:ndufb9|NDUFB9]]|0.411|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.411|
|[[:human genes:t:tbrg4|TBRG4]]|0.41|
|[[:human genes:g:grsf1|GRSF1]]|0.41|
|[[:human genes:u:uap1|UAP1]]|0.41|
|[[:human genes:c:cox4i1|COX4I1]]|0.409|
|[[:human genes:a:atp5j|ATP5J]]|0.408|
|[[:human genes:m:mterfd1|MTERFD1]]|0.407|
|[[:human genes:a:acad9|ACAD9]]|0.406|
|[[:human genes:m:mrps17|MRPS17]]|0.405|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.405|
|[[:human genes:c:cox7c|COX7C]]|0.404|
|[[:human genes:a:atp5h|ATP5H]]|0.403|
|[[:human genes:m:mrpl17|MRPL17]]|0.403|
|[[:human genes:a:atxn10|ATXN10]]|0.403|
|[[:human genes:a:atp5sl|ATP5SL]]|0.402|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.401|
|[[:human genes:p:ppcdc|PPCDC]]|0.401|
|[[:human genes:s:sdha|SDHA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1714
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCO2 Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>