======= SCRIB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCRIB
  * **<color #00a2e8>Official Name</color>**: scribble planar cell polarity protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23513|23513]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14160|Q14160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCRIB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCRIB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. {ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:15775968, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by organism of defense response of other organism involved in symbiotic interaction|
|suppression of defense response of other organism involved in symbiotic interaction|
|suppression by virus of host JAK-STAT cascade|
|modulation by symbiont of host receptor-mediated signal transduction|
|modulation by symbiont of host immune response|
|modulation by symbiont of host transmembrane receptor-mediated signal transduction|
|suppression by virus of host type I interferon-mediated signaling pathway|
|suppression by virus of host innate immune response|
|negative regulation by symbiont of host signal transduction pathway|
|suppression by virus of host STAT activity|
|negative regulation by symbiont of host receptor-mediated signal transduction|
|negative regulation by symbiont of host transmembrane receptor-mediated signal transduction|
|negative regulation by organism of immune response of other organism involved in symbiotic interaction|
|negative regulation by organism of signal transduction in other organism involved in symbiotic interaction|
|negative regulation by symbiont of host immune response|
|suppression of host defenses|
|negative regulation by symbiont of host innate immune response|
|suppression by virus of host STAT1 activity|
|modulation by symbiont of host innate immune response|
|suppression of defenses of other organism involved in symbiotic interaction|
|suppression by virus of host STAT2 activity|
|modulation by virus of host immune response|
|negative regulation by symbiont of host defense response|
|negative regulation of innate immune response in other organism|
|modulation by symbiont of host defense response|
|modulation by organism of immune response of other organism involved in symbiotic interaction|
|modulation by organism of innate immune response in other organism involved in symbiotic interaction|
|modulation by virus of host molecular function|
|modulation by symbiont of host signal transduction pathway|
|Scrib-APC-beta-catenin complex|
|neurotransmitter receptor transport postsynaptic membrane to endosome|
|negative regulation by symbiont of host molecular function|
|modulation by symbiont of host molecular function|
|suppression by virus of host molecular function|
|cochlear nucleus development|
|evasion or tolerance by virus of host immune response|
|protein localization to early endosome|
|evasion or tolerance of defense response of other organism involved in symbiotic interaction|
|evasion or tolerance of host immune response|
|evasion or tolerance of immune response of other organism involved in symbiotic interaction|
|evasion or tolerance of host defense response|
|protein localization to adherens junction|
|synaptic vesicle targeting|
|astrocyte cell migration|
|evasion or tolerance of host defenses by virus|
|modulation of signal transduction in other organism|
|response to host immune response|
|response to immune response of other organism involved in symbiotic interaction|
|avoidance of defenses of other organism involved in symbiotic interaction|
|evasion or tolerance of defenses of other organism involved in symbiotic interaction|
|avoidance of host defenses|
|extrinsic component of postsynaptic density membrane|
|modulation of signal transduction in other organism involved in symbiotic interaction|
|evasion or tolerance of host defenses|
|myelin sheath abaxonal region|
|response to defenses of other organism involved in symbiotic interaction|
|response to host|
|response to host defenses|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|neurotransmitter receptor transport, endosome to plasma membrane|
|pons development|
|modulation of molecular function in other organism involved in symbiotic interaction|
|auditory receptor cell stereocilium organization|
|endosome to plasma membrane protein transport|
|regulation of postsynaptic neurotransmitter receptor internalization|
|protein localization to endosome|
|protein localization to cell junction|
|ionotropic glutamate receptor complex|
|auditory receptor cell morphogenesis|
|negative regulation of type I interferon-mediated signaling pathway|
|positive regulation of receptor recycling|
|apoptotic process involved in morphogenesis|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|establishment of protein localization to postsynaptic membrane|
|auditory receptor cell development|
|modulation by virus of host cellular process|
|post-anal tail morphogenesis|
|establishment of apical/basal cell polarity|
|cell-cell contact zone|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|regulation of receptor recycling|
|modulation by symbiont of host cellular process|
|inner ear auditory receptor cell differentiation|
|apoptotic process involved in development|
|inner ear receptor cell stereocilium organization|
|retrograde transport, endosome to plasma membrane|
|regulation of defense response to virus by virus|
|mammary gland duct morphogenesis|
|modulation by virus of host morphology or physiology|
|ionotropic glutamate receptor binding|
|neurotransmitter receptor transport|
|hair cell differentiation|
|regulation of type I interferon-mediated signaling pathway|
|protein localization to postsynaptic membrane|
|glial cell migration|
|modification by symbiont of host morphology or physiology|
|receptor localization to synapse|
|inner ear receptor cell development|
|cell leading edge|
|mammary gland morphogenesis|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|neuroepithelial cell differentiation|
|receptor clustering|
|establishment or maintenance of epithelial cell apical/basal polarity|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|positive chemotaxis|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|columnar/cuboidal epithelial cell development|
|establishment of protein localization to plasma membrane|
|synaptic vesicle recycling|
|inner ear receptor cell differentiation|
|regulation of receptor internalization|
|negative regulation of innate immune response|
|mechanoreceptor differentiation|
|mammary gland epithelium development|
|negative regulation of cytokine-mediated signaling pathway|
|neural nucleus development|
|protein localization to synapse|
|synaptic vesicle exocytosis|
|negative regulation of response to cytokine stimulus|
|exocytic process|
|presynaptic membrane|
|localization within membrane|
|vesicle targeting|
|neural tube closure|
|tube closure|
|negative regulation of response to biotic stimulus|
|vesicle-mediated transport to the plasma membrane|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|activation of GTPase activity|
|primary neural tube formation|
|gland morphogenesis|
|regulation of receptor-mediated endocytosis|
|neurotransmitter secretion|
|signal release from synapse|
|cell-cell adherens junction|
|neural tube formation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|metencephalon development|
|establishment of cell polarity|
|ear morphogenesis|
|synaptic vesicle cycle|
|embryonic epithelial tube formation|
|mammary gland development|
|vesicle-mediated transport in synapse|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|negative regulation of immune response|
|hindbrain development|
|modification of morphology or physiology of other organism|
|interaction with host|
|neural tube development|
|regulation of cytokine-mediated signaling pathway|
|signal release|
|cell-cell junction|
|establishment of vesicle localization|
|regulation of response to cytokine stimulus|
|neurotransmitter transport|
|lamellipodium|
|protein localization to plasma membrane|
|vesicle localization|
|epithelial cell development|
|inner ear development|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|postsynaptic membrane|
|regulation of endocytosis|
|negative regulation of defense response|
|gliogenesis|
|negative regulation of multi-organism process|
|ear development|
|protein localization to cell periphery|
|endosomal transport|
|postsynaptic density|
|sensory organ morphogenesis|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|synapse|
|embryonic organ morphogenesis|
|negative regulation of mitotic cell cycle|
|epithelial tube morphogenesis|
|cadherin binding|
|epidermal cell differentiation|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|establishment of organelle localization|
|negative regulation of response to external stimulus|
|gland development|
|positive regulation of GTPase activity|
|epidermis development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell morphogenesis involved in neuron differentiation|
|establishment of protein localization to organelle|
|morphogenesis of an epithelium|
|embryonic organ development|
|trans-synaptic signaling|
|negative regulation of immune system process|
|regulation of innate immune response|
|synaptic signaling|
|wound healing|
|protein localization to membrane|
|regulation of GTPase activity|
|cell-cell adhesion|
|regulation of response to biotic stimulus|
|regulation of cellular protein localization|
|sensory organ development|
|cell junction|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell population proliferation|
|endocytosis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|organelle localization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|import into cell|
|epithelial cell differentiation|
|positive regulation of cell death|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|cell morphogenesis|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|exocytosis|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|intracellular protein transport|
|secretion by cell|
|neuron differentiation|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|tissue development|
|positive regulation of molecular function|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.3|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.92|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.84|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|4.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:shoc2|SHOC2]]|0.444|
|[[:human genes:n:nras|NRAS]]|0.432|
|[[:human genes:r:raf1|RAF1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCRIB Expression in NALM6 Cells: 7.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>