======= SCTR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCTR
  * **<color #00a2e8>Official Name</color>**: secretin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6344|6344]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47872|P47872]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCTR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCTR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|secretin receptor activity|
|cellular water homeostasis|
|diet induced thermogenesis|
|adaptive thermogenesis|
|regulation of appetite|
|positive regulation of cAMP-mediated signaling|
|cell volume homeostasis|
|response to dietary excess|
|peptide hormone binding|
|G protein-coupled peptide receptor activity|
|regulation of cAMP-mediated signaling|
|cytoplasmic microtubule|
|water homeostasis|
|regulation of cell size|
|regulation of synaptic plasticity|
|regulation of cellular component size|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to nutrient levels|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|brain development|
|cellular chemical homeostasis|
|head development|
|cellular homeostasis|
|central nervous system development|
|positive regulation of intracellular signal transduction|
|chemical homeostasis|
|G protein-coupled receptor signaling pathway|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11511
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCTR Expression in NALM6 Cells: 0.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>