======= SCYL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCYL1
  * **<color #00a2e8>Official Name</color>**: SCY1 like pseudokinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57410|57410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KG9|Q96KG9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCYL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCYL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607982|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI vesicle coat|
|cis-Golgi network|
|endoplasmic reticulum-Golgi intermediate compartment|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|protein tyrosine kinase activity|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|microtubule organizing center|
|cadherin binding|
|Golgi vesicle transport|
|peptidyl-amino acid modification|
|protein phosphorylation|
|Golgi apparatus|
|phosphorylation|
|DNA binding|
|ATP binding|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-4.25|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-3.97|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-3.78|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-3.55|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.09|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.65|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.61|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.55|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.52|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.52|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.51|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.45|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.36|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.32|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.3|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.26|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.21|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.19|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.14|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.12|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.12|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.05|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.04|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.99|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.95|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.9|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.85|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.83|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.82|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.71|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.71|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.7|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog7|COG7]]|0.5|
|[[:human genes:g:gpr107|GPR107]]|0.486|
|[[:human genes:u:unc50|UNC50]]|0.442|
|[[:human genes:t:tssc1|TSSC1]]|0.429|
|[[:human genes:c:cog6|COG6]]|0.417|
|[[:human genes:r:rab1b|RAB1B]]|0.414|
|[[:human genes:c:cog5|COG5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCYL1 Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>