======= SDC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDC4
  * **<color #00a2e8>Official Name</color>**: syndecan 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6385|6385]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31431|P31431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syndecan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thrombospondin receptor activity|
|positive regulation of extracellular exosome assembly|
|regulation of extracellular exosome assembly|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|costamere|
|positive regulation of focal adhesion assembly|
|fibronectin binding|
|inner ear receptor cell stereocilium organization|
|regulation of fibroblast migration|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|inner ear receptor cell development|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|inner ear receptor cell differentiation|
|protein kinase C binding|
|mechanoreceptor differentiation|
|regulation of cell-substrate junction assembly|
|negative regulation of T cell proliferation|
|regulation of focal adhesion assembly|
|glycosaminoglycan catabolic process|
|positive regulation of actin filament bundle assembly|
|aminoglycan catabolic process|
|regulation of adherens junction organization|
|negative regulation of mononuclear cell proliferation|
|positive regulation of organelle assembly|
|negative regulation of lymphocyte proliferation|
|regulation of stress fiber assembly|
|negative regulation of leukocyte proliferation|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of cell junction assembly|
|positive regulation of exocytosis|
|regulation of actomyosin structure organization|
|mesonephros development|
|neural tube closure|
|tube closure|
|regulation of actin filament bundle assembly|
|lysosomal lumen|
|primary neural tube formation|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|retinoid metabolic process|
|neural tube formation|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|negative regulation of T cell activation|
|regulation of cell-matrix adhesion|
|terpenoid metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of cell-substrate adhesion|
|embryonic epithelial tube formation|
|kidney epithelium development|
|epithelial tube formation|
|isoprenoid metabolic process|
|morphogenesis of embryonic epithelium|
|negative regulation of lymphocyte activation|
|tube formation|
|glycosaminoglycan metabolic process|
|regulation of T cell proliferation|
|neural tube development|
|aminoglycan metabolic process|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|carbohydrate derivative catabolic process|
|inner ear development|
|negative regulation of cell activation|
|positive regulation of supramolecular fiber organization|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|ear development|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|membrane raft|
|regulation of actin filament organization|
|kidney development|
|negative regulation of cell adhesion|
|renal system development|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|regulation of T cell activation|
|urogenital system development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|leukocyte migration|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|focal adhesion|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|negative regulation of immune system process|
|wound healing|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|sensory organ development|
|regulation of vesicle-mediated transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|cell surface|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of secretion by cell|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|tube development|
|regulation of cell migration|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|embryo development|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|localization of cell|
|cell motility|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.79|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.685|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15815
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDC4 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>