======= SDCCAG8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDCCAG8
  * **<color #00a2e8>Official Name</color>**: SHH signaling and ciliogenesis regulator SDCCAG8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10806|10806]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SQ7|Q86SQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDCCAG8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDCCAG8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis. {ECO:0000250|UniProtKB:Q80UF4}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|photoreceptor cell cilium|
|centriolar satellite|
|regulation of cilium assembly|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|establishment of cell polarity|
|neuron migration|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|ciliary basal body|
|centriole|
|tube formation|
|organelle localization by membrane tethering|
|cell-cell junction|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of cell cycle G2/M phase transition|
|regulation of organelle assembly|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|tube morphogenesis|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|organelle assembly|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|cell cycle process|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.87|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.78|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.7|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.74|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.87|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.09|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDCCAG8 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>