======= SDE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDE2
  * **<color #00a2e8>Official Name</color>**: SDE2 telomere maintenance homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=163859|163859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IQ49|Q6IQ49]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620743|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S- phase progression (PubMed:27906959). {ECO:0000269|PubMed:27906959}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|damaged DNA binding|
|cellular response to UV|
|regulation of cell cycle arrest|
|cellular response to light stimulus|
|response to UV|
|protein processing|
|cellular response to radiation|
|DNA replication|
|protein maturation|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to radiation|
|cell division|
|protein ubiquitination|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|response to abiotic stimulus|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.77|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.81|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.72|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.73|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.73|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.76|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.78|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.8|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.8|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.8|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.88|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.89|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.04|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.428|
|[[:human genes:r:rpf1|RPF1]]|0.405|
|[[:human genes:r:rrp36|RRP36]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDE2 Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>