======= SDHA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDHA
  * **<color #00a2e8>Official Name</color>**: succinate dehydrogenase complex flavoprotein subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6389|6389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31040|P31040]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDHA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDHA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600857|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225). {ECO:0000269|PubMed:20484225, ECO:0000305|PubMed:24781757}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Succ DH flav C|
|Pyr redox 2|
|FAD binding 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane succinate dehydrogenase complex|
|succinate dehydrogenase activity|
|mitochondrial electron transport, succinate to ubiquinone|
|succinate dehydrogenase (ubiquinone) activity|
|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|
|succinate metabolic process|
|tricarboxylic acid cycle|
|flavin adenine dinucleotide binding|
|electron transfer activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|dicarboxylic acid metabolic process|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|drug metabolic process|
|nucleolus|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|phosphorylation|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.98|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.9|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.72|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.74|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.526|
|[[:human genes:t:triap1|TRIAP1]]|0.499|
|[[:human genes:v:vezt|VEZT]]|0.487|
|[[:human genes:d:dpagt1|DPAGT1]]|0.475|
|[[:human genes:r:rnmt|RNMT]]|0.47|
|[[:human genes:t:thg1l|THG1L]]|0.47|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.47|
|[[:human genes:e:eny2|ENY2]]|0.465|
|[[:human genes:a:alg5|ALG5]]|0.464|
|[[:human genes:d:dars2|DARS2]]|0.462|
|[[:human genes:t:tsen54|TSEN54]]|0.458|
|[[:human genes:g:gmppb|GMPPB]]|0.454|
|[[:human genes:b:bcs1l|BCS1L]]|0.453|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.453|
|[[:human genes:t:trnt1|TRNT1]]|0.45|
|[[:human genes:a:atp5d|ATP5D]]|0.449|
|[[:human genes:p:pelo|PELO]]|0.448|
|[[:human genes:a:alg13|ALG13]]|0.447|
|[[:human genes:m:med16|MED16]]|0.444|
|[[:human genes:a:atp5o|ATP5O]]|0.44|
|[[:human genes:e:exoc4|EXOC4]]|0.438|
|[[:human genes:a:atxn10|ATXN10]]|0.438|
|[[:human genes:s:slc25a26|SLC25A26]]|0.436|
|[[:human genes:c:chchd4|CHCHD4]]|0.435|
|[[:human genes:p:ppa2|PPA2]]|0.434|
|[[:human genes:a:alg1|ALG1]]|0.431|
|[[:human genes:a:atp5a1|ATP5A1]]|0.425|
|[[:human genes:c:cox16|COX16]]|0.425|
|[[:human genes:m:mrps34|MRPS34]]|0.424|
|[[:human genes:u:uap1|UAP1]]|0.423|
|[[:human genes:c:cbfb|CBFB]]|0.423|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:r:rpp21|RPP21]]|0.417|
|[[:human genes:a:atp5b|ATP5B]]|0.417|
|[[:human genes:m:mrps14|MRPS14]]|0.416|
|[[:human genes:d:dhps|DHPS]]|0.415|
|[[:human genes:f:fh|FH]]|0.412|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:t:tmem41b|TMEM41B]]|0.41|
|[[:human genes:u:uqcrq|UQCRQ]]|0.41|
|[[:human genes:s:slc25a19|SLC25A19]]|0.41|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.41|
|[[:human genes:d:dap3|DAP3]]|0.409|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.409|
|[[:human genes:t:tufm|TUFM]]|0.407|
|[[:human genes:l:lsm10|LSM10]]|0.406|
|[[:human genes:g:gemin5|GEMIN5]]|0.405|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.404|
|[[:human genes:g:gfpt1|GFPT1]]|0.404|
|[[:human genes:a:alg2|ALG2]]|0.403|
|[[:human genes:t:trmt5|TRMT5]]|0.402|
|[[:human genes:m:mrps26|MRPS26]]|0.402|
|[[:human genes:r:rtcb|RTCB]]|0.402|
|[[:human genes:s:srp14|SRP14]]|0.402|
|[[:human genes:a:atp5j|ATP5J]]|0.402|
|[[:human genes:p:pam16|PAM16]]|0.401|
|[[:human genes:t:timm22|TIMM22]]|0.401|
|[[:human genes:s:sco2|SCO2]]|0.4|
|[[:human genes:t:txnrd1|TXNRD1]]|0.4|
|[[:human genes:h:hspd1|HSPD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|2/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDHA Expression in NALM6 Cells: 8.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>