======= SDR16C5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDR16C5
  * **<color #00a2e8>Official Name</color>**: short chain dehydrogenase/reductase family 16C member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=195814|195814]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3Y7|Q8N3Y7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDR16C5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDR16C5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269|PubMed:18926804}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratinocyte proliferation|
|retinal metabolic process|
|negative regulation of histone acetylation|
|positive regulation of histone deacetylation|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of protein acetylation|
|retinol dehydrogenase activity|
|positive regulation of protein deacetylation|
|regulation of histone deacetylation|
|activating transcription factor binding|
|retinol metabolic process|
|negative regulation of histone modification|
|regulation of protein deacetylation|
|cellular aldehyde metabolic process|
|transcriptional repressor complex|
|regulation of histone acetylation|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|regulation of protein acetylation|
|primary alcohol metabolic process|
|lipid droplet|
|epithelial cell proliferation|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|retinoid metabolic process|
|diterpenoid metabolic process|
|chromatin|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|negative regulation of chromosome organization|
|isoprenoid metabolic process|
|regulation of histone modification|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|hormone metabolic process|
|transcription corepressor activity|
|alcohol metabolic process|
|transcription factor binding|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|cell population proliferation|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|negative regulation of transcription by RNA polymerase II|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.502|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDR16C5 Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>